- Chloroprocaine should only be administered by a clinician having adequate knowledge for management of dose related toxicities and acute emergencies in a medical facility with adequate resources
- Administer test dose and monitor CNS and cardiovascular toxicity; signs of intrathecal administration
- Post-marketing reports of chrondrolysis in patients who received intra-articular infusions of local anesthetics following arthroscopic and other surgical procedures
- Careful and constant monitoring of cardiovascular and respiratory (adequacy of ventilation) vital signs and the patient’s state of consciousness should be accomplished after each local anesthetic injection.
- Risk of severe persistent hypertension if vasopressors are administered in presence of ergot-type oxytocic drugs
- To avoid intravascular injection, frequent aspirations before and during administration of chloroprocaine are recommended
- Repeated doses of local anesthetics may cause significant increases in plasma levels due to slow accumulation; reduce dose in elderly, debilitated, and children
- Local anesthetics with vasoconstrictors should be used cautiously in patients with peripheral vascular disease and hypertensive vascular disease
- In retrobulbar block, lack of corneal sensation precedes external ocular muscle akinesia; do not rely on lack of corneal sensation
- Monitor cardiovascular and respiratory vital signs
Cautions: Use cautiously in
Pregnancy Category:C
Breastfeeding: Safety unknown; an alternate drug may be preferred, especially while nursing a newborn or preterm infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 13 September 2010). Manufacturer advises caution.
