Adult Dosing

Allergic rhinitis

• 4 mg PO q4-6 hrs; Alt: 12 mg Extended Release TABS PO bid
• Max: 24 mg/day

Pediatric Dosing

Allergic rhinitis

• Child 6-11 yrs: 2 mg PO q 4-6 hrs. MAX: 12 mg/day
• Child 12 yrs: 4 mg PO q4-6 hrs; Alt: 12 mg Extended Release TABS PO bid. Max: 24 mg/day

[Outline]

• Adult Dosing
• Pediatric Dosing

• Relief of allergic symptoms caused by histamine release

• Hypersensitivity to any ingredients of the product
• Children < 2 yrs

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Assess patients for allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing) before starting therapy and periodically thereafter
• Review therapy to determine if it needs to be continued without change or if a dose change is indicated
• Overdosage of antihistamines may cause hallucinations, convulsions, and death. Antihistamines may diminish mental alertness. In young children, they may produce paradoxical excitation. Use of antihistamines is contraindicated in children < 2 yrs
• Sustained-release form not recommended in children younger than 12 yr of age
• Chlorpheniramine may impair coordination and judgement

Cautions: Use cautiously in

• Renal impairment
• Hepatic impairment
• Hx of asthma
• COPD
• Increased IOP
• Angle closure glaucoma
• Cardiovascular disease
• Hypertension
• CNS depressant use
• PUD
• Prostatic hypertrophy
• Bladder neck obstruction
• Hyperthyroidism
• Poor CYP2D6 metabolizer
• GI obstruction
• Pediatric patients < 6 yrs
• Geriatric population

Aller-Chlor, Chlor-Trimetron interacts with :

	Aricept
	Aricept ODT
	Donepezil
	Exelon
	Galantamine
	Razadyne
	Razadyne ER
	Rivastigmine

Pregnancy Category:B

Breastfeeding: Small occasional doses of chlorpheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause adverse effects in the infant or interfere with lactation, particularly when used in combination with a sympathomimetic agent or when lactation is not well established. The nonsedating antihistamines should be preferred. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 14 May 2010).

• CNS: Drowsiness, dizziness, paradoxical CNS stimulation (in children), incoordination, headache, seizures, toxic psychosis
• EENT: Blurred vision, diplopia, acute labyrinthitis
• CV: Hypertension, arrhythmias , hypotension, palpitations, tachycardia
• RESP: Thickening of bronchial secretions, chest tightness, respiratory depression, wheezing
• GI: Epigastric discomfort, dry mouth, constipation , obstruction
• HEMA: Hemolytic anemia, thrombocytopenia, agranulocytosis, pancytopenia, leukopenia
• GU: Retention , urinary hesitancy, dysuria, erectile dysfunction
• MISC: Anaphylactic/anaphylactoid reactions, dry mucous membranes, diaphoresis, photosensitivity

• Competitively antagonizes central and peripheral H1 receptors (non-selective antihistamine); suppresses the medullary cough center (antitussive); has antidyskinetic, antiemetic and sedative effects due to its anticholinergic properties
• Well absorbed following oral administration
• Metabolized by GI tract, liver; CYP450: 2D6, 3A4 substrate
• Renally excreted (minimally unchanged)
• Half-life: 21-27 hrs

US Trade Name(s)

• Aller-Chlor
• Chlor-Trimetron

US Availability

chlorpheniramine (generic)

• TABS: 4 mg
• ETABS: 12 mg

Aller-Chlor

• SYRUP: 2 mg/5 mL
• TABS: 4 mg

Chlor-Trimetron

• ETABS: 12 mg

Canadian Trade Name(s)

• Chlor-Tripolon
• Chlor-Tripolon Day and Night
• Novo-Pheniram

Canadian Availability

chlorpheniramine (generic)

• TABS: 4 mg

Chlor-Tripolon

• TABS: 4 mg
• ETABS: 12 mg

Chlor-Tripolon Day and Night

• KIT: 4 mg (TABS) + 12 mg (ETABS)

Novo-Pheniram

• TABS: 4 mg

UK Trade Name(s)

• Piriton
• ALLERcalm Allergy Relief

UK Availability

chlorpheniramine (generic)

• TABS: 4 mg
• SOLN: 2 mg/5 mL (150 mL)

Piriton

• TABS: 4 mg
• SYRUP: 2 mg/5 mL (150 mL)

ALLERcalm Allergy Relief

• TABS:4mg

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

ENT

Antihistamines

Allergy & Immunology

Antihistamines

Drug Name: 12 HR Chlor-Trimeton 12 MG Extended Release Tablet

Ingredient(s): Chlorpheniramine

Imprint: CTM;12

Color(s): Orange

Shape: Round

Size (mm): 7.00

Score: 1

Inactive Ingredient(s): acacia / calcium sulfate / carnauba wax / lactose monohydrate / oleic acid / povidone / starch, corn / sucrose / talc / tribasic calcium phosphate / white wax / zein / magnesium stearate / rosin / titanium dioxide

Drug Label Author:
Schering Plough HealthCare Products

DEA Schedule:
Non-Scheduled