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Interacting Drugs

OBJECT DRUGS

PRECIPITANT DRUGS


Comment:

Theophylline is metabolized by CYP1A2 and to a lesser extent CYP3A4. Fluvoxamine is a potent inhibitor of CYP1A2, and may produce dramatic increases in theophylline plasma concentrations; theophylline toxicity is likely to occur.


Class 2: Use Only if Benefit Felt to Outweigh Risk