Adult Dosing
Diagnosis of bronchial hyperreactivity
- 5 breaths NEB per concentration
- Max: 188.88 total cumulative units
Notes:- Use increasing serial concentrations of 0.025 to 25 mg/ml per standardized inhalation procedure
- Cumulative units = # breaths x solution conc.
- Measure FEV1 at baseline and after 5 breaths at each conc.
- Stop test if FEV1 decrease is >20%
Pediatric Dosing
Diagnosis of bronchial hyperreactivity
Child >5 yrs
- 5 breaths NEB per concentration
- Max: 188.88 total cumulative units
Notes:- Use increasing serial concentrations 0.025 to 25 mg/ml per standardized inhalation procedure
- Cumulative units = # breaths x solution conc.
- Measure FEV1 at baseline and after 5 breaths at each conc.
- Stop test if FEV1 decrease is >20%
[Outline]
See Supplemental Patient Information
- Therapy is for diagnostic purposes only used by inhalation route; perform inhalation challenge under supervision of physician trained in technique, contraindications, warnings, and precautions, and respiratory distress management [US Black Box Warning]
- Make emergency equipment and medication immediately available to treat acute respiratory distress [US Black Box Warning]
- Bronchoconstriction and decreased respiratory function may occur; suspend therapy immediately if severe bronchoconstriction occurs. Reverse immediately with rapid acting inhaled beta agonist bronchodilator [US Black Box Warning]
- Inhalation challenge should not be performed if clinically apparent asthma, wheezing, or very low baseline pulmonary function tests include FEV1 <70% predicted [US Black Box Warning]
- Cautiously administer in patients with epilepsy, cardiovascular disease accompanied by bradycardia, vagotonia, peptic ulcer disease, thyroid disease, urinary tract obstruction only if benefit outweighs the potential risks
Cautions: Use cautiously in
- Epilepsy
- Cardiovascular disease
- Vagotonia
- Peptic ulcer disease
- Thyroid disease
- Urinary tract obstruction
- Pregnancy
Supplemental Patient Information
- Instruct patients regarding symptoms that may occur as a result of the test and how such symptoms can be managed
- Female patient should inform physician if she is pregnant, or the date of her last onset of menses, or the date and result of her last pregnancy test
Pregnancy Category:C
Breastfeeding: Safety unknown. Manufacturer advises not to administer to a nursing mother.
