Renal Dose Adjustment (Based on CrCl)
- Renal impairment
- Immediate release
- 30-80 mL/min: Dose adjustment not defined
- < 30 mL/min: 20 mg PO qhs
- Extended release
- CrCl < 30 mL/min: Contraindicated
Hepatic Dose Adjustment
- Moderate to severe impairment: Use with caution; dose adjustment not defined
- Concomitant use with other anticholinergic agents may cause anticholinergic events like dry mouth and constipation; avoid concomitant administration
- Overexposure to heat may increase risk of heat stroke due to decreased production of sweat
- Do not consume alcohol within 2 hours of administration
- Monitor CrCl at baseline
- Therapy may cause anticholinergic central nervous system (CNS) effects such as dizziness, confusion, hallucinations and somnolence. Monitor for signs of anticholinergic CNS effects, especially after initiating treatment or increasing the dose. Consider dose reduction or discontinuation if patient experiences anticholinergic CNS effects. Advise patients not to drive or operate heavy machinery during treatment period
Cautions: Use cautiously in
- Severe renal impairment (refer dose adjustment section)
- Moderate to severe hepatic impairment
- GI obstructive disorders
- Ulcerative colitis (may decrease gastrointestinal motility)
- Intestinal atony (may decrease gastrointestinal motility)
- Myasthenia gravis (may decrease gastrointestinal motility)
- Controlled angle-closure glaucoma (requires careful monitoring)
- Bladder neck obstruction (risk of urinary retention)
- Autonomic neuropathy
- Hyperthyroidism
- Coronary artery disease
- Congestive heart failure
- Hypertension
- Prostatic hyperplasia
- Arrhythmias
- Tachycardia
- Geriatric patients (sensitivity to anticholinergic effects)
Sanctura, Sanctura XR interacts with :
Pregnancy Category:C
Breastfeeding: Safety unknown; excreted in breastmilk of lactating rats. Manufacturer advises caution.
Pricing data from www.DrugStore.com in U.S.A.
- Sanctura XR 60 MG CP24 [Bottle] (ALLERGAN DERMATOLOGICS)
30 mg = $196
90 mg = $560.96 - Sanctura 20 MG TABS [Bottle] (ALLERGAN DERMATOLOGICS)
30 mg = $99.99
90 mg = $275.99
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
