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Interacting Drugs

OBJECT DRUGS

Angiotensin Receptor Blockers (ARBs):

PRECIPITANT DRUGS


Comment:

Patients on ACE inhibitors have developed severe hypotension after starting tizanidine therapy; theoretically, a similar reaction could occur if tizanidine were added to ARB therapy. Tizanidine, like the antihypertensive drug clonidine, is an alpha-2 adrenergic agonist, and may have additive hypotensive effects with ARBs.


Class 3: Assess Risk & Take Action if Necessary