Adult Dosing![navigator.gif](../../Images/Navigator.gif)
Envenomation due to bite by a snake of the genus Pseudonaja
- 1 vial [1000 U] diluted with Hartmanns solution (1:10) should be administered slowly by IV infusion
- If severe coagulopathy or myocardial depression is present, patient may require several vials
Notes:- Do not remove the splint and pressure bandage until antivenom is available for infusion, as removal can precipitate significant effects of systemic envenoming
- Manage severe cases of systemic envenoming in an ICU
- Monitor patients for at least 6 hours after the conclusion of the antivenom infusion
- Premedicate with 0.25 mL adrenaline (1:1000) SC and antihistamine IV to reduce the chance of anaphylactic shock
- If severe anaphylaxis is seen post antivenom administration, discontinue therapy, administer O2 and adrenaline (1:1000) IM at following doses:
- Small adults (<50 kg): 0.25 mL
- Average adults (50-100 kg): 0.5 mL
- Large adults (>100 kg): 0.75 mL
- If no or minimal response to initial IM dose of adrenaline is seen, administer the same dose of adrenaline (diluted to 1:10000) slowly into an IV line; repeat q5 minutes depending on response
- Administer corticosteroid IV x 1 or orally for 4-5 days to those receiving multiple doses of antivenom to avoid delayed serum sickness
- Use only once and discard any residue
Pediatric Dosing![navigator.gif](../../Images/Navigator.gif)
Envenomation due to bite by a snake of the genus Pseudonaja
- 1 vial [1000 U] diluted with Hartmanns solution (1:10 or 1:5 for small children) should be administered slowly by IV infusion
- Children may become critically ill sooner and may require more antivenom
Notes:- Do not remove the splint and pressure bandage until antivenom is available for infusion, as removal can precipitate significant effects of systemic envenoming
- Manage severe cases of systemic envenoming in an ICU
- Monitor patients for at least 6 hours after the conclusion of the antivenom infusion
- Premedicate with 0.25 mL adrenaline (1:1000) SC and antihistamine IV to reduce the chance of anaphylactic shock
- If severe anaphylaxis is seen post antivenom administration, discontinue therapy, administer O2 and adrenaline (1:10000) IM at following doses:
- Children
12 yrs: 0.25 mL/yr of age - If no or minimal response to initial IM dose of adrenaline is seen, administer the same dose of adrenaline (diluted to 1:10000) slowly into an IV line; repeat q5 minutes depending on response
- Administer corticosteroid PO x 4-5 days in order to avoid delayed serum sickness
- Use only once and discard any residue
[Outline]
Pregnancy Category:NR
Breastfeeding: Safety unknown.
![flag_usa32.png](../../Images/flag_usa32.png)
US Trade Name(s)
US Availability
![flag_canada32.png](../../Images/flag_canada32.png)
Canadian Trade Name(s)
Canadian Availability
![flag_uk32.png](../../Images/flag_uk32.png)
UK Trade Name(s)
UK Availability
![flag_australia32.png](../../Images/flag_australia32.png)
Australian Trade Name(s)
Australian Availability
antivenom brown snake (generic)
[Outline]
![flag_usa32.png](../../Images/flag_usa32.png)
![flag_canada32.png](../../Images/flag_canada32.png)
![flag_uk32.png](../../Images/flag_uk32.png)
![flag_australia32.png](../../Images/flag_australia32.png)