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Interacting Drugs

OBJECT DRUGS

Vinca Alkaloids:

PRECIPITANT DRUGS

Calcium Channel Blockers:


Comment:

Vinca alkaloids appear to be metabolized by CYP3A4 and reports have described severe toxicity in patients receiving CYP3A4 inhibitors such as verapamil. P-glycoprotein inhibition may also be involved in these interactions.


Class 2: Use Only if Benefit Felt to Outweigh Risk