Adult Dosing
Early/advanced chronic simple glaucoma and glaucoma secondary to cataract surgery
- Instill 1 gtt in the eye(s) twice daily, at bedtime and in the morning
- Alternatively, instill 1 gtt in the eye(s) qod-qd at bedtime
Notes:- For topical ophthalmic use only
- May be co-administered with epinephrine, a carbonic anhydrase inhibitor, or both
- Instill the daily dose or one of the two daily doses just before retiring to avoid inconvenience due to miosis
Pediatric Dosing
Accommodative esotropia
Diagnosis
- Instill 1 gtt once daily in each eye at bedtime for 2-3 wks
Treatment
- Following the initial period of treatment for diagnostic purposes, instill 1 gtt every other day in both eyes at bedtime
- Max: 1 gtt once daily in both eyes at bedtime as long as the drug is well tolerated
Note:
- For topical ophthalmic use only
[Outline]
See Supplemental Patient Information
- Exercise caution while administering succinylcholine prior to or during general anesthesia to patients receiving anticholinesterase medication due to the risk of possible respiratory or cardiovascular collapse
- Caution should be exercised in treating glaucoma with this product in patients who are receiving systemic anticholinesterase medications concomitantly for myasthenia gravis due to possible adverse additive effects
- Conduct gonioscopy prior to therapy initiation and perform routine examination to detect lens opacity during therapy
- Avoid anticholinesterase therapy or use cautiously in case of a quiescent uveitis or its history due to the possible risk of intense and persistent miosis and ciliary muscle contraction
- Digital compression of the nasolacrimal ducts for 1-2 min following drug instillation is recommended to minimize drainage into the nasal chamber. Wash hands thoroughly following instillation to prevent possible skin absorption
- Discontinue the drug temporarily or permanently in case of cardiac irregularities
- Temporarily discontinue the drug, if required, in case of salivation, urinary incontinence, diarrhea, profuse sweating, muscle weakness, or respiratory difficulties
- Anticholinesterase drugs may be used prior to ophthalmic surgery only as a considered risk due to the possibility of hyphema
- Warn patients receiving echothiophate iodide of the possible additive systemic effects from absorption of carbamate- or organophosphate-type insecticides and pesticides. Recommend wearing respiratory masks and frequent washing and clothing changes in the event of exposure to such pesticides
Cautions: Use cautiously in
Supplemental Patient Information
- Advise patients receiving echothiophate iodide to wear respiratory masks, and wash hands and change clothes frequently during exposure to carbamate-or organophosphate-type pesticides
Pregnancy Category:C
Breastfeeding: No data available regarding the use of echothiophate ophthalmic drops during breastfeeding. As echothiophate is a quaternary ammonium compound, it is not likely to pass into the breastmilk or reach the bloodstream of the nursing infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACTlast accessed 06 December 2011). As per manufacturer's data, due to the potential for adverse reactions from the drug in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, analyzing the importance of the drug to the mother.
