Adult Dosing

Schistosomiasis

• 60 mg/kg/day PO divided tid x 1 day
• Give at intervals of not less than 4 hrs and not more than 6 hrs

Clonorchiasis

• 75 mg/kg/day PO divided tid 1 day
• Give at intervals of not less than 4 hrs and not more than 6 hrs

Opisthorchiasis

• 75 mg/kg/day PO divided tid 1 day
• Give at intervals of not less than 4 hrs and not more than 6 hrs

Pediatric Dosing

Schistosomiasis

Child >4 yrs

• 60 mg/kg/day PO divided tid x 1 day
• Give at intervals of not less than 4 hrs and not more than 6 hrs

Clonorchiasis

Child >4 yrs

• 75 mg/kg/day PO divided tid 1 day
• Give at intervals of not less than 4 hrs and not more than 6 hrs

Opisthorchiasis

Child >4 yrs

• 75 mg/kg/day PO divided tid 1 day
• Give at intervals of not less than 4 hrs and not more than 6 hrs

• Wash down unchewed with water during meals. Chewing or keeping the tablet or its pieces in the mouth can cause a bitter taste promoting gagging or vomiting
• Safety and effectiveness in pediatric patients <4 yrs of age have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of infections due to all species of schistosoma (e.g. Schistosoma mekongi, Schistosoma japonicum, Schistosoma mansoni and Schistosoma hematobium), and infections due to the liver flukes, clonorchis sinensis/ Opisthorchis viverrini

• Hypersensensitivity to any of the ingredients of the product
• Ocular schistosomiasis
• Ocular cysticercosis
• Concomitant strong CYP450 inducers

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Child Pugh class B or C: Use with caution

• Monitor patients suffering from cardiac irregularities
• Minimal increases in liver enzymes have been reported in some patients
• When schistosomiasis or fluke infection is found to be associated with cerebral cysticercosis, hospitalization is advised for the duration of treatment
• Advise patients to avoid driving or operating machinery on the day of treatment and the following day
• Concomitant administration of CYP450 inducing drugs like rifampin and antiepileptic drugs (phenytoin, phenobarbital and carbamazepine), and dexamethasone, may reduce plasma levels of praziquantel to sub-therapeutic levels
• Should not be administered to individuals reporting a history of epilepsy and/or other signs of potential central nervous systems involvement such as subcutaneous nodules suggestive of cysticercosis, as Biltricide can exacerbate central nervous system pathology due to schistosomiasis

Pregnancy Category:B

Breastfeeding: Praziquantel is excreted in human breast milk. Women should not nurse on the day of treatment and during the subsequent 72 hrs.

• CNS: Malaise, headache, fever, drowsiness, dizziness, intracranial hypertension, arachnoiditis, meningism, convulsions
• CV: Arrhythmias, bradycardia, ventricular fibrillation, AV block, hypotension
• DERM: Urticaria
• GI: Abdominal discomfort, w/ or w/out nausea, diarrhea
• HEPATIC: Increased liver enzymes
• HEMA: Eosinophilia
• DERM: Pruritus
• MISC: Pyrexia

• Antihelminthic; dislodges the worm by inducing rapid contraction and paralysis of schistosome musculature, by increasing cell membrane permeability to calcium
• Metabolized by liver
• Excreted in urine: 80% (<0.1% unchanged)
• Half-Life: 0.8-1.5 hrs

US Trade Name(s)

• Biltricide

US Availability

Biltricide

• TABS: 600 mg

Canadian Trade Name(s)

• Biltricide

Canadian Availability

Biltricide

• TABS: 600 mg

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• Biltricide

Australian Availability

Biltricide

• TABS: 600 mg

[Outline]

Antimicrobials

Antiparasitics

Antihelmintics

Infectious Disease

Antiparasitics

Antihelmintics

Pricing data from www.DrugStore.com in U.S.A.

• Biltricide 600 MG TABS [Bottle] (SCHERING)
  6 mg = $93.22
  18 mg = $255.79

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

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