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Interacting Drugs

OBJECT DRUGS

PRECIPITANT DRUGS

Enzyme Inhibitors:


Comment:

Inhibition of CYP3A4 can result in carbamazepine toxicity, usually within 2-3 days of starting the inhibitor; most patients who start a CYP3A4 inhibitor while on carbamazepine will develop clinical evidence of carbamazepine toxicity. The effect of danazol may be delayed by 1-2 weeks. Not all known CYP3A4 inhibitors have been studied with carbamazepine, but assume they interact until proven otherwise.


Class 3: Assess Risk & Take Action if Necessary