Adult Dosing

Superficial ocular infections

• Apply q3-4 hrs x7-10 days, depending on the severity of the infection

Pediatric Dosing

Superficial ocular infections

• Apply q3-4 hrs x7-10 days, depending on the severity of the infection

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by susceptible organisms

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Indicated for ophthalmic use only
• Ophthalmic ointments may retard corneal healing
• Long-term use may result in overgrowth of nonsusceptible organisms, including fungi; institute appropriate measures if this occurs

Pregnancy Category:C

Breastfeeding: Probably safe. Bacitracin is poorly absorbed following topical application; hence, considered to pose a low risk to the nursing infant. Polymyxin B is also poorly absorbed after topical application, hence may have minimal excretion in breast milk. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 23 June 2011).

• LOCAL: Eye irritation, eye redness, itching, eyelid edema, conjunctival edema, conjunctival erythema
• HYPERSENSITIVITY: Allergic reactions, anaphylaxis
• MISC: Superinfection (prolonged use)

Bacitracin

• Polypeptide antibiotic; interferes with bacterial cell wall synthesis by inhibiting regeneration of phospholipid receptors involved with peptidoglycan synthesis
• Minimal systemic absorption following ophthalmic administration
• Not metabolized significantly; CYP450: none
• Excretion: Unknown
• Half-life: Unknown

Polymyxin B

• Cyclic lipopeptide antibiotic; increases cell wall permeability by interacting with the phospholipid components of the bacterial cell membrane
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

US Trade Name(s)

• Only generic available

US Availability

bacitracin/polymyxin B (generic)

• OPH OINT: [500 U/10000 U]/g

Canadian Trade Name(s)

• Optimyxin
• Polysporin

Canadian Availability

Optimyxin, Polysporin (bacitracin/polymyxin)

• OPH OINT: [500 U/10000 U]/g

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Antimicrobials

Ophthalmic Anti-infectives

Infectious Disease

Ophthalmic Anti-infectives

Ophthalmic

Ophthalmic Anti-infectives