Adult Dosing

Oropharyngeal Candidiasis

• One 10 mg troche (dissolve slowly) PO 5 times/daily x 7-14 consecutive days

Prophylaxis of oropharyngeal candidiasis in immunocompromised patients

• One 10 mg PO troche tid x 7-14 consecutive days
• Note: Dissolve slowly in mouth

Pediatric Dosing

• Note: Safety and effectiveness of clotrimazole in children <3 years of age has not been established

Oropharyngeal Candidiasis

• One 10 mg troche (dissolve slowly) PO 5 times/daily x 7-14 consecutive days; dissolve slowly in mouth

Prophylaxis of oropharyngeal candidiasis in immunocompromised patients

• One 10 mg PO troche tid x 7-14 consecutive days
• The safety and efficacy of the prophylactic use of clotrimazole troches in children has not been established

• Oropharyngeal candidiasis
• Prophylaxis of oropharyngeal candidiasis in immunocompromised patients

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal Impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic Impairment: Dose adjustment not defined

See Supplemental Patient Information

• Not recommended for the treatment of systemic mycoses including systemic candidiasis
• Diagnosis should be confirmed by KOH smear and/or culture
• Abnormal LFTs including elevated SGOT have been reported; periodically monitor liver function tests in patients with pre-existing hepatic impairment

Cautions: Use cautiously in

• Hepatic impairment
• Pediatric patients

Supplemental Patient Information

• Instruct patients to allow each troche to dissolve slowly in the mouth in order to achieve maximum effect of the medication

Mycelex interacts with :

	Abstral
	Actiq
	Afinitor
	Alfenta
	Alfentanil
	Astagraf XL
	Cyclosporine
	Dolophine
	Duragesic
	Everolimus
	Fentanyl
	Fentora
	Gengraf
	Hecoria
	Lazanda
	Methadone
	Methadose
	Neoral
	Onsolis
	Oxecta
	Oxycodone
	Oxycontin
	OxyFast
	Percocet
	Prograf
	Protopic
	Rapamune
	Restasis
	Roxicodone
	Sandimmune
	Sirolimus
	Sublimaze
	Subsys
	Sufenta
	Sufentanil
	Tacrolimus
	Westadone

Pregnancy Category:C

Breastfeeding: Due to poor oral bioavailability, it is unlikely to adversely affect the breastfed infant. This information is based upon Lactmed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 20 October 2010)

• GI: Nausea, vomiting, unpleasant mouth sensations, abdominal cramps
• DERM: Pruritus
• HEPA: Abnormal liver function tests, elevated SGOT levels

• Broad-spectrum antifungal agent; inhibits the growth of pathogenic yeasts by altering the permeability of cell membranes
• Minimal systemic absorption
• Primarily excreted in urine
• Half-life: Unknown

US Trade Name(s)

• Mycelex (Discontinued)

US Availability

clotrimazole (generic)

• TROC: 10 mg

Mycelex

• TROC: 10 mg

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

Antimicrobials

Antifungals (Systemic)

Azole Antifungals

Infectious Disease

Antifungals (Systemic)

Azole Antifungals