Adult Dosing

Dermal ulcer or burn

• Apply collagenase ointment once daily within the area of wound; or more frequently if the dressing is soiled

• Prior to application of collagenase, clean the wound of debris and digested material by gently rubbing with a gauze pad saturated with normal saline solution, or a collagenase-compatible cleansing agent, followed by a normal saline rinse
• Apply appropriate topical antibiotic powder prior to the application of collagenase
• Apply collagenase ointment directly to the wound (avoid healthy surrounding skin) or to a sterile gauze pad which is then applied to the wound
• Discontinue the use of collagenase when debridement of necrotic tissue is complete and granulation tissue is well established

Pediatric Dosing

• Safety and effectiveness have not been established in pediatric patients

[Outline]

• Adult Dosing
• Pediatric Dosing

• To promote debridement of chronic dermal ulcers and severely burned areas

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Optimal pH range of collagenase is 6-8, enzyme's activities decreases with higher or lower pH conditions hence take appropriate precautions in these conditions
• Certain detergents and heavy metal ions, such as mercury and silver which are used in some antiseptics, adversely affect the enzymatic activity, hence when use of such material is suspected, clean the site carefully by repeated washings with normal saline before applying collagenase ointment
• Avoid the use of soak containing metal ions or acidic solutions because of the metal ion and low pH
• Apply the ointment carefully within the area of wound as transient erythema has been reported in the surrounding tissue especially when collagenase application is not confined to the wound
• Closely monitor debilitated patient for systemic bacterial infections, as there is theoretical possibility that debriding enzymes can increase the risk of bacteremia

Caution: Use cautiously in

• Debilitated patient

Pregnancy Category: Unknown

Breastfeeding: Unknown

• MISC: Allergic sensitivity or toxic reactions

• Anti-Ulcer agent; by hydrolyzing the peptide bonds of undenatured and denatured collagen, collagenase digest collagen in necrotic tissue at physiological pH, thus contributing towards the formation of granulation tissue and subsequent epithelization of dermal ulcers and severely burned areas
• Absorbtion: Unknown
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

US Trade Name(s)

• Santyl

US Availability

Santyl

• OINT: 250 U/g

Canadian Trade Name(s)

• Santyl

Canadian Availability

Santyl

• OINT: 250 U/g

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Dermatologic

Dermatologic Topical Agents

Debriding Agents