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Interacting Drugs

OBJECT DRUGS

Anticoagulants, Oral:

PRECIPITANT DRUGS

Antimicrobials:


Comment:

These antimicrobials inhibit CYP3A4 and may increase the plasma concentration of apixaban and rivaroxaban. Since apixaban and rivaroxaban are also substrates for P-glycoprotein, precipitant drugs that inhibit both CYP3A4 and P-glycoprotein may produce a larger increase in anticoagulant concentrations.


Class 3: Assess Risk & Take Action if Necessary