See Supplemental Patient Information
- Hydrocodone can produce dose-related respiratory depression when used in high dose or in sensitive patients, by acting directly on the brain stem respiratory center, also the center that controls respiratory rhythm and produce irregular and periodic breathing
- Use of narcotics in the presence of head injury, other intracranial lesions or a preexisting increase in intracranial pressure, markedly exaggerates its respiratory depressant effects and its capacity to elevate cerebrospinal fluid pressure and further more produce adverse reactions which may obscure the clinical course of patients with head injuries
- The diagnosis or clinical course of patients with acute abdominal conditions is obscured with the administration of narcotics
- Hydrocodone is an opioid agonist and is a Schedule III controlled substance. It has the potential for being abused and is sought by people with addiction disorders, and are subject to diversion. Hence physician or pharmacist should be concerned about an increased risk of misuse, abuse or diversion when prescribing or dispensing hydrocodone or its combination
- Hydrocodone suppresses the cough reflex, use cautiously in patient with pulmonary diseases and postoperatively
Cautions: Use cautiously in
- Renal impairment
- Hepatic impairment
- Hypothyroidism
- Addison's disease
- Prostatic hypertrophy
- Urethral stricture
- Pulmonary diseases
- Head injury
- Increased intracranial pressure
- Intracranial lesion
- Alcohol abuse
- Elderly patients
- Debilitated patients
Supplemental Patient Information
- Advise patients to avoid potentially hazardous tasks such as driving a car or operating machinery as hydrocodone like other opioids impairs the mental and/or physical abilities for performing these tasks
- Advise patients to avoid alcohol and other CNS depressants as they produce an additive CNS depression
- Caution other sources of acetaminophen; including over the counter use. Maximum daily intake of acetaminophen is 4gm/day
Pregnancy Category:C
Breastfeeding: Amounts of acetaminophen excreted in breast milk are much less than doses usually given to infants, hence it is good choice for analgesia, and fever reduction in nursing mothers. Very rarely adverse effect appears in breastfed infants. Maternal use of maximum dosages of oral narcotics while breastfeeding can cause infant drowsiness in breastfed infants, particularly newborns are sensitive to even small dosages of narcotic analgesics, in the first week of life, however small volumes of colostrum is secreted in the first 2 to 3 days postpartum hence newborn's dosage is limited. Once the mother's milk comes in, it is best to avoid oral hydrocodone (and combinations) and administer nonnarcotic analgesic if necessary. Maximum recommended dosage is 30 mg/day. Monitor the infant for drowsiness, adequate weight gain, and developmental milestones, immediately contact the physician if baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 9 March 2011). As per manufacturer data acetaminophen in small amount in breast milk and it is unknown whether hydrocodone is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from hydrocodone and acetaminophen, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
US Trade Name(s)
- Anexsia
- Co-Gesic
- Hycet
- Lorcet
- Lorcet plus
- Lortab
- Lortab Elixir
- Maxidone
- Norco
- Vicodin (Discontinued)
- Zamicet
- Zydone
US Availability
acetaminophen/hydrocodone
- TABS
- 300 mg/5 mg
- 300 mg/7.5 mg
- 300 mg/10 mg
- 325 mg/2.5 mg
- 325 mg/5 mg
- 325 mg/7.5 mg
- 325 mg/10 mg
- 500 mg/2.5 mg
- 500 mg/5 mg
- 500 mg/7.5 mg
- 500 mg/10 mg
- 650 mg/5 mg
- 650 mg/7.5 mg
- 650 mg/10 mg
- 660 mg/10 mg
- 750 mg/7.5 mg
- 750 mg/10 mg
- ORAL SOLN
- [300 mg/10 mg]/15 mL
- [325 mg/7.5 mg]/15 mL
- [325 mg/10 mg]/15 mL
- [500 mg/7.5 mg]/15 mL
- [500 mg/10 mg]/15 mL
Anexsia (acetaminophen/hydrocodone)
- TABS
- 325 mg/5 mg
- 325 mg/7.5 mg
- 500 mg/5 mg
- 600 mg/7.5 mg
- 750 mg/10 mg
Co-Gesic (acetaminophen/hydrocodone)
Hycet (acetaminophen/hydrocodone)
- SOLN: [325 mg/7.5 mg]/15 mL
Lorcet (acetaminophen/hydrocodone)
Lorcet Plus (acetaminophen/hydrocodone)
Lortab (acetaminophen/hydrocodone)
Lortab Elixir (acetaminophen/hydrocodone)
- SOLN: [500 mg/7.5 mg]/15 mL
Maxidone (acetaminophen/hydrocodone)
Norco (acetaminophen/hydrocodone)
- TABS
- 325 mg/7.5 mg
- 325 mg/10 mg
Vicodin (acetaminophen/hydrocodone)
Zamicet (acetaminophen/hydrocodone)
- SOLN: [325 mg/10 mg]/15 mL
Zydone (acetaminophen/hydrocodone)
- TABS
- 400 mg/5 mg
- 400 mg/7.5 mg
- 400 mg/10 mg
Canadian Trade Name(s)
Canadian Availability
UK Trade Name(s)
UK Availability
Australian Trade Name(s)
Australian Availability
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Vicodin 5-500 MG TABS [Bottle] (ABBOTT)
30 mg = $50.99
90 mg = $133.97 - Lortab 10 10-500 MG TABS [Bottle] (UCB PHARMA)
30 mg = $62.99
90 mg = $165.97 - Norco 5-325 MG TABS [Bottle] (WATSON LABS)
30 mg = $52.65
90 mg = $132.76 - Zydone 7.5-400 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
30 mg = $32.99
90 mg = $72.58 - Lortab 5-500 MG TABS [Bottle] (UCB PHARMA)
30 mg = $57.99
90 mg = $155.98 - Zamicet 10-325 MG/15ML SOLN [Bottle] (HAWTHORN PHARMACEUTICALS)
473 15ml = $164.88
1419 15ml = $468.25 - Zydone 5-400 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
30 mg = $27.99
90 mg = $65.97 - Lorcet Plus 7.5-650 MG TABS [Bottle] (FOREST)
30 mg = $48.49
90 mg = $131.14 - Lortab 7.5-500 MG/15ML ELIX [Bottle] (UCB PHARMA)
120 15ml = $47.99
360 15ml = $119.97 - Norco 7.5-325 MG TABS [Bottle] (WATSON LABS)
30 mg = $57.23
90 mg = $160.24 - Lortab 7.5 7.5-500 MG TABS [Bottle] (UCB PHARMA)
30 mg = $64.99
90 mg = $173.97 - Lorcet 10/650 10-650 MG TABS [Bottle] (FOREST)
30 mg = $57.99
90 mg = $159.97 - Zydone 10-400 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
30 mg = $31.99
90 mg = $83.97 - Norco 10-325 MG TABS [Bottle] (WATSON LABS)
30 mg = $69.95
90 mg = $204.56
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
46 kg: 15 mL PO q4-6 hrs; Max: 90 mL/day