Adult Dosing
Analgesic, antipyretic, antihistaminic
- 2 tabs [650 mg/4 mg] PO q4-6 hrs PRN
- Max: 12 tabs [3900 mg/24 mg]/day
Pediatric Dosing
Analgesic, antipyretic, antihistaminic
- 6-11 yrs
- 1 tab [325 mg/2 mg] PO q4-6 hrs PRN
- Max: 5 tabs [1625 mg/10 mg]/day
- >12 yrs
- 2 tabs [650 mg/4 mg] PO q4-6 hrs PRN
- Max: 12 tabs [3900 mg/24 mg]/day
See Supplemental Patient Information
- Severe liver damage may occur on exceeding recommended dosages, concurrent use with other drugs containing acetaminophen. Adults having
3 alcoholic drinks everyday are susceptible for development of manifestations related to severe liver damage. Avoid using acetaminophen/chlorpheniramine combination drug with any other drug containing acetaminophen component - Obtain medical history of patients for presence of any liver disease, breathing problems such as emphysema or chronic bronchitis, glaucoma, urinary obstruction, or prostatic hypertrophy; also, ask patients whether they are receiving treatment with any blood thinning agents such as warfarin, sedatives or tranquilizers
- Excitability may occur in all patients undergoing treatment with acetaminophen/chlorpheniramine, especially in children
- Drowsiness may occur during therapy; use caution when performing hazardous tasks
- Avoid concomitant use with alcoholic beverages, sedatives and tranquilizers as these may increase drowsiness
- Discontinue therapy and consult a clinician if new symptoms occur, redness or swelling is present, pain gets worse or persists for more than 5 days in children or 10 days in adults, and if fever gets worse or lasts more than 3 days
Cautions: Use cautiously in
- Hepatic impairment
- Renal impairment
- Asthma
- Bladder neck obstruction
- CNS depressant use
- COPD
- GI obstruction
- Angle-closure glaucoma
- Increased intraocular pressure
- Lower respiratory tract symptoms
- Prostatic hypertrophy
- Peptic ulcer disease
- Geriatric patients
- Patients <6 yrs
Supplemental Patient Information
- Advise patients receiving therapy to exercise caution while driving a motor vehicle or operating machinery as therapy may cause drowsiness
Pregnancy Category:B (acetaminophen), B (chlorpheniramine)
Breastfeeding: Acetaminophen component of this combination drug is a good choice for analgesia and fever reduction in nursing mothers. Amounts excreted in milk are much less than doses usually given to infants. Adverse effects in breastfed infants appear to be rare. Small, occasional doses of chlorpheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause adverse effects in the infant or interfere with lactation, particularly in combination with a sympathomimetic agent or when lactation is not well established. However, the nonsedating antihistamines are preferred alternatives . This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT). Maternal medication of acetaminophen is usually compatible with breastfeeding; no observable change was seen in the nursing infant while the mother was ingesting the compound. This information is based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776/T6 last accessed 22 June, 2011). Manufacturer advises to consult a health professional.
US Trade Name(s)
US Availability
Coricidin HBP Cold & Flu (acetaminophen/chlorpheniramine)
Canadian Trade Name(s)
- Coricidin II Cold and Flu
Canadian Availability
Coricidin II Cold and Flu (acetaminophen/chlorpheniramine)
UK Trade Name(s)
UK Availability
Australian Trade Name(s)
- Chemists' Own Coldeze Tablets
Australian Availability
Chemists' Own Coldeze Tablets(paracetamol/chlorpheniramine)