See Supplemental Patient Information
- Discontinue drug if laryngeal edema, angioedema, or jaundice occurs
- Monitor liver function
- Monitor for neutropenia in collagen vascular and/or renal disease and for hyperkalemia in diabetics
- Black patients may have higher risk of angioedema than non-black patients. Control mild heart failure (eg, with digitalis, diuretics)
Use cautiously in
- Renal impairment
- Hepatic impairment
- CHF
- Cerebrovascular or ischemic heart disease
- Renal artery or aortic stenosis
- Dialysis (esp. high-flux membrane)
- Salt/volume depletion
- Black patients
- Antigen desensitization treatment
- Surgery
- AV conduction or neuromuscular transmission disorders
- Hypertrophic cardiomyopathy
- Hyponatremia
- LDL apheresis with dextran
- Smoking habit changes
- Elderly patients
Supplemental Patient Information
- Advise patients not to use trandolapril/verapamil if they are pregnant as it could harm the unborn baby
- Instruct patient to contact physican if pregnancy is detected before taking the drug
- Contact physican if signs of an allergic reaction like hives, severe stomach pain, difficulty breathing, swelling of your face, lips, tongue, or throat occurs
Pregnancy Category:C (1st trimester) and D (2nd and 3rd trimesters)
Breastfeeding: Safety unknown for trandolapril; alternate drug might be preferred, especially while nursing a newborn baby. According to manufacturer's data, trandolapril should not be administered to nursing women. Verapamil is poorly excreted in breast milk; would not be expected to cause any adverse effects in breastfed infants, especially if the infant is >2 months. Verapamil information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT) Verapamil is compatible and considered safe with breastfeeding based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776 last accessed 10 December 2010 ). However, manufacturer advices not to administer trandolapril/verapamil to nursing mothers
US Trade Name(s)
US Availability
trandolapril/verapamil (generic)
- 1 mg (IR TABS); 240 mg (ER TABS)
- 2 mg (IR TABS); 180 mg (ER TABS)
- 2 mg (IR TABS); 240 mg (ER TABS)
- 4 mg (IR TABS); 240 mg (ER TABS)
Tarka (trandolapril/verapamil)
- 1 mg (IR TABS); 240 mg (ER TABS)
- 2 mg (IR TABS); 180 mg (ER TABS)
- 2 mg (IR TABS); 240 mg ER TABS)
- 4 mg (IR TABS); 240 mg (ER TABS)
Canadian Trade Name(s)
Canadian Availability
Tarka (trandolapril/verapamil
- 1 mg (IR TABS); 180 mg (ER TABS)
- 2 mg (IR TABS); 180 mg ER TABS)
- 1 mg (IR TABS); 240 mg (ER TABS)
- 2 mg (IR TABS); 240 mg (ER TABS)
- 4 mg (IR TABS); 240 mg (ER TABS)
UK Trade Name(s)
UK Availability
Tarka (trandolapril/verapamil)
- 2 mg (IR TABS); 180 mg (ER TABS)
Australian Trade Name(s)
Australian Availability
Tarka (trandolapril/verapamil)
- 2 mg (IR TABS); 180 mg (ER TABS)
Tarka (trandolapril/verapamil)
- 2 mg (IR TABS); 180 mg (ER TABS)
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Tarka 2-240 MG TBCR [Bottle] (ABBOTT)
30 mg = $113.99
90 mg = $319.98 - Trandolapril-Verapamil HCl 4-240 MG TBCR [Bottle] (GLENMARK PHARMACEUTICALS)
30 mg = $89.99
90 mg = $249.97 - Tarka 1-240 MG TBCR [Bottle] (ABBOTT)
30 mg = $105.99
90 mg = $285.96 - Tarka 2-180 MG TBCR [Bottle] (ABBOTT)
30 mg = $113.99
90 mg = $329.97 - Trandolapril-Verapamil HCl 2-240 MG TBCR [Bottle] (GLENMARK PHARMACEUTICALS)
30 mg = $89.99
90 mg = $249.97 - Tarka 4-240 MG TBCR [Bottle] (ABBOTT)
30 mg = $115.99
90 mg = $334.98 - Trandolapril-Verapamil HCl 2-180 MG TBCR [Bottle] (GLENMARK PHARMACEUTICALS)
30 mg = $89.99
90 mg = $249.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.