Adult Dosing

Treatment of fungal infections including tinea pedis, tinea cruris and tinea corporis

• CRE: Apply a thin layer of cream to the affected and surrounding skin areas qd for 2 weeks
• GEL: Gently massage into the affected and surrounding skin areas bid for 2 weeks

Note:

• Intended for topical use only
• Re-evaluate the patient after 4 weeks if there is no clinical improvement

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Topical treatment of fungal infections including interdigital tinea pedis, tinea cruris and tinea corporis in adult patients 18 yrs of age

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Recommended for topical and external use only; not for ophthalmic, oral, or intravaginal use
• Do not apply the medication in the eyes, mouth, nose, and other mucous membranes
• Therapy may cause transient irritation, burning, or stinging
• Discontinue therapy if irritation or sensitivity develops and institute appropriate therapy

Caution: Use cautiously in

• Lactation

Supplemental Patient Information

• Instruct patients to avoid using occlusive dressings or wrappings unless directed by their physician
• Advise patients to wash their hands thoroughly after applying the cream or gel
• Inform patients to keep the product away from the eyes, nose, mouth and other mucous membranes
• Advise patients to discontinue therapy and promptly contact their physician if irritation or sensitivity develops following therapy use

Pregnancy Category:B

Breastfeeding: No data available regarding the use of topical naftifine during lactation. It is indicated that only 4-6% of the drug is absorbed and very little amount is expected to be excreted into breast milk. Topical application of the cream or gel to the nipple area should be avoided. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 02 May 2011). Manufacturer advises caution.

• DERM: Rash, burning, stinging, dryness, erythema, pruritus, local irritation

• Antifungal agent; interferes with fungal cell membrane ergosterol synthesis by inhibiting the enzyme squalene 2, 3-epoxidase
• Bioavailability: Unknown
• Absorbed systemically 6% (cream) and 4.2% (gel)
• Excretion: Urine and feces
• Half-life: Approximately 2-3 days

US Trade Name(s)

• Naftin

US Availability

Naftin

• GEL: 1%
• CRE: 1%
• CRE: 2%

Canadian Trade Name(s)

• Naftin

Canadian Availability

Naftin

• GEL: 1%
• CRE: 1%

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Antimicrobials

Dermatologic Topical Agents

Antifungals

Infectious Disease

Dermatologic Topical Agents

Antifungals

Dermatologic

Dermatologic Topical Agents

Antifungals

Pricing data from www.DrugStore.com in U.S.A.

• Naftin 1 % CREA [Tube] (MERZ PHARMACEUTICAL)
  30 % = $302
  90 % = $839.98
• Naftin 1 % GEL [Tube] (MERZ PHARMACEUTICAL)
  60 % = $296.84
  180 % = $810.79
• Naftin 1 % CREA [Tube] (MERZ PHARMACEUTICAL)
  90 % = $280.39
  270 % = $789.82
• Naftin 1 % GEL [Tube] (MERZ PHARMACEUTICAL)
  90 % = $292
  270 % = $835.97
• Naftin 1 % GEL [Tube] (MERZ PHARMACEUTICAL)
  40 % = $297.32
  120 % = $830.95
• Naftin 1 % CREA [Tube] (MERZ PHARMACEUTICAL)
  60 % = $301
  180 % = $885.95

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.