Adult Dosing
Type II diabetes mellitus (NIDDM)
- Starting and maintenance dose: 120 mg PO tid before meals
- May give 60 mg PO tid in patients who are close to goal HbA1C when treatment is initiated
Notes:- Dose of 60-120 mg PO tid can be used alone or in combination with metformin or thiazolidinedione
- Should be taken 1-30 minutes before meals; skip dose if meal is skipped to reduce the risk of hypoglycemia
Pediatric Dosing
- Safety and effectiveness in pediatric patients have not been established
[Outline]
See Supplemental Patient Information
- Nateglinide may produce hypoglycemia; geriatric patients, malnourished patients, and those with adrenal or pituitary insufficiency or severe renal impairment are at greater risk of hypoglycemia
- Increased risk of hypoglycemia may be due to strenuous physical exercise, ingestion of alcohol, insufficient caloric intake on an acute or chronic basis, or combinations with other oral antidiabetic agents
- Hypoglycemia may be difficult to recognize in patients having autonomic neuropathy or those taking beta-blockers
- Nateglinide should be taken before meals to reduce the risk of hypoglycemia
- Transient loss of glycemic control may result with fever, trauma, infection, or surgery; discontinue nateglinide and initiate insulin therapy
- Assess therapy response periodically using glucose values and glycosylated hemoglobin levels
Cautions: Use cautiously in
- Moderate-severe hepatic impairment
- Malnutrition
- Adrenal insufficiency
- Autonomic neuropathy
- Elderly patients
Supplemental Patient Information
- Educate patients about the risks and management of hypoglycemia
Pregnancy Category:C
Breastfeeding: Because no information is available on the use of nateglinide during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 4 April 2011). It is unknown whether nateglinide is excreted in human milk. As per manufacturer's data, nateglinide should not be administered to a nursing woman.
Pricing data from www.DrugStore.com in U.S.A.
- Starlix 120 MG TABS [Bottle] (NOVARTIS)
30 mg = $70.99
90 mg = $194.96 - Nateglinide 60 MG TABS [Bottle] (PAR)
30 mg = $47.99
90 mg = $135.97 - Starlix 60 MG TABS [Bottle] (NOVARTIS)
30 mg = $66.99
90 mg = $176.98
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
