Adult Dosing

Minor cuts, scrapes, burns

• Apply on the affected area qd-tid

Pediatric Dosing

Minor cuts, scrapes, burns

• Apply on the affected area qd-tid

[Outline]

• Adult Dosing
• Pediatric Dosing

• First aid to help prevent infections in minor cuts, scrapes, and burns

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustments

• Recommended for external use only
• Do not apply in the eyes, over large areas of the body, or if the patient is allergic to any of the ingredients
• Contact healthcare provider before using it in case of deep or puncture wounds, animal bites, or serious burns
• Suspend therapy and consult a physician if the condition persists or gets worse or if a rash or other allergic reaction develops
• Do not use this product for more than 1 wk unless directed by a physician
• Prolonged use may result in overgrowth of nonsusceptible microorganisms, including fungi

Pregnancy Category:C

Breastfeeding: Bacitracin is poorly absorbed following topical application; hence, considered a low risk to the nursing infant. Water-miscible ointments applied to the breast may expose the infant to high levels of mineral paraffins via licking. Polymyxin B is minimally absorbed after topical application; therefore, it poses a low risk to the nursing infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 24 June 2011).

• LOCAL: Itching, rash, swelling, irritation
• DERM: Contact dermatitis (bacitracin topical)
• GU: Nephrotoxicity (polymyxin B topical)
• EENT: Ototoxicity (polymyxin B topical)
• HYPERSENSITIVITY: Severe allergic reactions

Bacitracin

• Polypeptide antibiotic; inhibits bacterial cell wall synthesis, active against bacterial protoplasts and damages the bacterial plasma membrane
• Minimal systemic absorption
• Not metabolized significantly
• Excretion: Unknown
• Half-life: Unknown

Polymyxin B

• Cyclic lipopeptide antibiotic; increases bacterial cell permeability by interacting with the lipopolysaccharide of the cytoplasmic outer membrane of Gram-negative bacteria, causing cell death
• Not absorbed
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

US Trade Name(s)

• Polysporin

US Availability

bacitracin/polymyxin B (generic)

• OTC OINT: [500 U/10,000 U]/g

Polysporin (bacitracin/polymyxin B )

• OTC OINT: [500 U/10,000 U]/g
• OTC PWDR: [500 U/10,000 U]/g

Canadian Trade Name(s)

• Antibiotic Ointment
• Bacimyxin Onguent
• Band-Aid Brand Adhesive Bandages Plus Antibiotic
• Bioderm
• Polyderm
• Polysporin
• Polytopic

Canadian Availability

Antibiotic Ointment, Bacimyxin Onguent, Band-Aid Brand Adhesive Bandages Plus Antibiotic, Bioderm, Polyderm, Polysporin , Polytopic(bacitracin/polymyxin B )

• OTC OINT: [500 U/10,000 U]/g

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Antimicrobials

Dermatologic Topical Agents

Antibiotics

Infectious Disease

Dermatologic Topical Agents

Antibiotics

Dermatologic

Dermatologic Topical Agents

Antibiotics

Pricing data from www.DrugStore.com in U.S.A.

• Bacitracin-Polymyxin B 500-10000 UNIT/GM OINT [Tube] (BAUSCH & LOMB)
  3.5 gm = $31.99
  10.5 gm = $75.97

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.