OBJECT DRUGS
Tetracyclines:
- Demeclocycline (Declomycin)
- Doxycycline (Vibramycin, etc.)
- Minocycline (Minocin, etc.)
- Oxytetracycline
- Tetracycline
PRECIPITANT DRUGS
Absorption Inhibitors:
- Antacids
- Bismuth (Pepto Bismol)
- Didanosine (Videx, etc.)
- Iron Products
- Sucralfate (Carafate)
- Zinc
Comment:
The absorption of tetracyclines may be reduced by agents containing cations such as aluminum, magnesium, and to a lesser extent, iron. Doxycycline may be less susceptible to these interactions than other tetracyclines, and does not appear to be affected significantly by iron.
Class 3: Assess Risk & Take Action if Necessary
- Circumvent/Minimize: Give the tetracycline 2 hours before or 6 hours after the absorption inhibitor to minimize the interaction. Enteric coated didanosine (Videx EC) does not appear to interact.
- Monitor: Watch for reduced tetracycline efficacy in patients taking absorption inhibitors.