Adult Dosing
Moderate to moderately severe pain
- Acetaminophen 300 mg to 650 mg/oxycodone 2.5 mg to 10 mg every 6 hours as needed; Max 4000 mg acetaminophen/day
Note:
- In patients who are on long term therapy, and who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient
Management of acute pain (Xartemis XR)
- 2 tab PO q12hr without regard to food; use formulation when opioid therapy required and alternative treatment options inadequate
Note:
- Swallow whole with enough water to ensure complete swallowing after placing in mouth; do not break, chew, cut, crush, dissolve or split the tablets
Pediatric Dosing
- Safety and effectiveness in pediatric patients have not been established
[Outline]
- Oxycodone is an opioid agonist and is a Schedule III controlled substance. It has the potential for being abused and is sought by abusers and people with addiction disorders, and is subject to diversion. Hence physician or pharmacist should be concerned about an increased risk of misuse, abuse or diversion when prescribing or dispensing hydrocodone or its combination
- Oxycodone can produce dose-related respiratory depression when used in high dose or in sensitive patients, by acting directly on the brain stem respiratory center, also the center that controls respiratory rhythm and produce irregular and periodic breathing. If respiratory depression occurs, use reversal agent such as naloxone hydrochloride
- Use of narcotics in the presence of head injury, other intracranial lesions or a preexisting increase in intracranial pressure, markedly exaggerates its respiratory depressant effects and its capacity to elevate cerebrospinal fluid pressure and further more produce adverse reactions which may obscure the clinical course of patients with head injuries
- Severe hypotension has been reported with oxycodone, particularly in individuals whose ability to maintain blood pressure has been compromised. Use cautiously in patients in circulatory shock, as it may further reduce cardiac output and blood pressure
- Hepatotoxicity and severe hepatic failure has occurred in chronic alcoholics with therapeutic dose, use cautiously in patients with liver disease
- Use with extreme caution in combination with CNS depressant drugs and only if the benefits of opioid analgesia outweigh the known risks of respiratory depression, altered mental state, and postural hypotension
- The diagnosis or clinical course of patients with acute abdominal conditions is obscured with the administration of narcotics
- Oxycodone can aggravate convulsions in patients with convulsive disorders
Cautions: Use with caution in
- Renal impairment
- Hepatic impairment
- Pulmonary diseases
- Head injury
- Increased intracranial pressure
- Intracranial lesion
- Seizure disorder
- Acute abdomen
- Alcohol abuse
- CNS depression
- Hypothyroidism
- Addison's disease
- Prostatic hypertrophy
- Urethral stricture
- Delirium tremens
- Kyphoscoliosis with respiratory depression
- Myxedema
- Toxic psychosis
- Concomitant CNS depressant
- Elderly patients
- Debilitated patients
Pregnancy Category:C
Breastfeeding: Amounts of acetaminophen excreted in breast milk are much less than doses usually given to infants, hence it is good choice for analgesia, and fever reduction in nursing mothers. Very rarely adverse effect appears in breastfed infants. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 17 March 2011). Maternal use of maximum dosages of oral narcotics while breastfeeding can cause infant drowsiness in breastfed infants, particularly newborns are sensitive to even small dosages of narcotic analgesics, in the first week of life, however small volumes of colostrum is secreted in the first 2 to 3 days postpartum hence newborn's dosage is limited. Once the mother's milk comes in, it is best to avoid oral oxycodone (and combinations) and administer nonnarcotic analgesic if necessary. Maximum recommended dosage is 30 mg/day. Monitor the infant for drowsiness, adequate weight gain, and developmental milestones, immediately contact the physician if baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 17 March 2011). Both acetaminophen and oxycodone are excreted in small amount in breast milk. Because of the possibility of sedation and/or respiratory depression in the infant manufacturer recommends avoiding nursing while receiving oxycodone and acetaminophen tablets.
US Trade Name(s)
- Endocet
- Magnacet
- Percocet
- Primalev
- Roxicet
- Roxilox
- Tylox
- Xolox
- Xartemis XR
US Availability
acetaminophen/oxycodone (generic)
- TABS
- 300 mg/2.5 mg
- 300 mg/5 mg
- 300 mg/7.5 mg
- 300 mg/10 mg
- 325 mg/2.5 mg
- 325 mg/5 mg
- 325 mg/7.5 mg
- 325 mg/10 mg
- 400 mg/2.5 mg
- 400 mg/5 mg
- 400 mg/7.5 mg
- 400 mg/10 mg
- 500 mg/7.5 mg
- 500 mg/10 mg
- 650 mg/10 mg
Endocet (acetaminophen/oxycodone)
- TABS
- 325 mg/5 mg
- 325 mg/7.5 mg
- 325 mg/10 mg
- 500 mg/7.5 mg
- 650 mg/10 mg
Magnacet (acetaminophen/oxycodone)
- TABS
- 400 mg/5 mg
- 400 mg/7.5 mg
- 400 mg/10 mg
Percocet (acetaminophen/oxycodone)
- TABS
- 325 mg/2.5 mg
- 325 mg/5 mg
- 325 mg/7.5 mg
- 325 mg/10 mg
- 500 mg/7.5 mg
- 650 mg/10 mg
Primalev (acetaminophen/oxycodone)
- TABS
- 300 mg/5 mg
- 300 mg/7.5 mg
- 300 mg/10 mg
Roxicet (acetaminophen/oxycodone)
Roxilox (acetaminophen/oxycodone)
Tylox (acetaminophen/oxycodone)
Xolox (acetaminophen/oxycodone)
Xartemis XR (acetaminophen/oxycodone)
Canadian Trade Name(s)
- Endocet
- Percocet
- Percocet-Demi
- Ratio-Oxycocet
- Rivacocet
Canadian Availability
acetaminophen/oxycodone (generic)
oxycodone-Acet (generic)
Endocet (acetaminophen/oxycodone)
Percocet (acetaminophen/oxycodone)
Percocet-Demi (acetaminophen/oxycodone)
Ratio-Oxycocet (acetaminophen/oxycodone)
Rivacocet (acetaminophen/oxycodone)
UK Trade Name(s)
UK Availability
Australian Trade Name(s)
Australian Availability
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Roxicet 5-325 MG/5ML SOLN [Bottle] (ROXANE)
500 5ml = $49.99
1500 5ml = $135.96 - Percocet 5-325 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
20 mg = $94.99
30 mg = $141.97 - Endocet 10-650 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
20 mg = $35.99
30 mg = $48.97 - Percocet 7.5-500 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
20 mg = $100.99
30 mg = $150.98 - Percocet 10-325 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
20 mg = $127.99
30 mg = $191.99 - Tylox 5-500 MG CAPS [Bottle] (MCNEIL)
20 mg = $49.54
30 mg = $74.31 - Percocet 10-650 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
20 mg = $130.99
30 mg = $195.97 - Endocet 10-325 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
20 mg = $34.99
30 mg = $52.48 - Percocet 2.5-325 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
30 mg = $90.99
60 mg = $180.98 - Endocet 5-325 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
30 mg = $17.99
90 mg = $53.97 - Roxicet 5-325 MG TABS [Bottle] (ROXANE)
20 mg = $12.99
30 mg = $14.99 - Percocet 7.5-325 MG TABS [Bottle] (ENDO PHARMACEUTICALS)
20 mg = $90.99
30 mg = $135.98
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
