Adult Dosing

American Trypanosomiasis (Chagas Disease)

• 5-7 mg/kg PO per day in 2 divided doses x 60 days (According to CDC)

Pediatric Dosing

American Trypanosomiasis (Chagas Disease)

• (Child < 12 years): 10 mg/kg per day orally in 2 divided doses for 60 days (According to CDC)

[Outline]

• Adult Dosing
• Pediatric Dosing

• American Trypanosomiasis (Chagas Disease)

• Hypersensitivity to any of the ingredients of the product
• Severe hepatic disease/failure
• Severe renal disease/failure

• N/A

Renal Dose Adjustment

• Renal impairment: Contraindicated

Hepatic Dose Adjustment

• Hepatic impairment: Contraindicated

• Benznidazole should not be used concurrently with alcohol; accumulation of acetaldehyde may lead to disulfiram-like effects causing extreme discomfort such as abdominal cramps, nausea, vomiting, headache, or flushing
• Concurrent use with aspirin may increase the risk of bleeding
• When used concurrently with anticoagulants, coumarin-derivatives, such as warfarin the effect of the drug may be potentiated
• Benznidazole may rarely decrease the concentration of leukocytes and platelets; closely monitor CBC
• Adverse Reactions then to be more frequent and severe with increasing age

Cautions: Use cautiously in:

• Pregnancy
• Breastfeeding

Pregnancy Category: Unknown; World Health Organization (WHO) prescribing information does not recommend the use of benznidazole during the first trimester of pregnancy.

Breastfeeding: It is not known whether benznidazole is distributed into breast milk; caution advised

• CNS: Peripheral neuropathy, insomnia
• HYPERSENSITIVITY: Allergic dermatitis
• METABOLIC: Anorexia, weight loss

• Trypanocidal; inhibits protein and ribonucleic acid (RNA) synthesis in the trypanosome parasite
• Rapidly absorbed from the gastrointestinal tract
• Excreted inurine (60 to 67%) and feces (22 to 28%)
• Half-life: Approximately 10.5 to 13.6 hours; average 12 hours

US Trade Name(s)

• N/A

US Availability

• N/A

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Antimicrobials

Antiparasitic Agents