OBJECT DRUGS

• Flibanserin (Addyi)

PRECIPITANT DRUGS

Calcium Channel Blockers:

• Diltiazem (Cardizem, etc.)
• Verapamil (Isoptin, etc.)

Comment:

Flibanserin is a CYP3A4 substrate, and CYP3A4 inhibitors such as diltiazem or verapamil may increase the risk of flibanserin toxicity.

Class 3: Assess Risk & Take Action if Necessary

• Consider Alternative: Calcium channel blockers other than diltiazem and verapamil are unlikely to inhibit the metabolism of flibanserin.
• Monitor: If flibanserin is used with CYP3A4 inhibitors, monitor for evidence of flibanserin toxicity such as hypotension, fainting, and CNS depression. Reduce flibanserin dose as needed.