Adult Dosing

Allergic rhinitis, Urticaria and other alllergic conditions

• Start 4 mg PO tid; usual range: 4-20 mg/day PO. [Max: 0.5 mg/kg/day]

Pediatric Dosing

Allergic rhinitis, Urticaria and other alllergic conditions

• Child 2-6 yrs: Start 0.25 mg/kg/day PO div bid-tid; usual range: 2 mg PO bid-tid. [Max: 12 mg/day]
• Child 7-14 yrs: Start 0.25 mg/kg/day PO div bid-tid; usual range: 4 mg PO bid-tid. [Max: 16 mg/day]

[Outline]

• Adult Dosing
• Pediatric Dosing

• Perennial and seasonal allergic rhinitis
• Vasomotor rhinitis
• Allergic conjunctivitis due to inhalant allergens and foods
• Mild, uncomplicated allergic skin manifestations of urticaria and angioedema
• Amelioration of allergic reactions to blood or plasma
• Cold urticaria
• Dermatographism
• Therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations

• Hypersensitivity to any of the ingredients of the product
• Newborn or premature infants
• Nursing mothers
• Angle-closure glaucoma
• MAOI therapy
• Stenosing peptic ulcer
• Pyloroduodenal obstruction
• Bladder neck obstruction
• Elderly, debilitated patients

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined, caution advised

• Overdosage may produce hallucinations, central nervous system depression, convulsions, respiratory and cardiac arrest, and death particularly in infants and young children
• Therapy may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation
• Cyproheptadine may have additive effects with alcohol and other CNS depressants
• Warn patients about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery
• In elderly patients therapy may cause dizziness, sedation, and hypotension
• Use with caution in patients with history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, hypertension as cyproheptadine has an atropine-like action

Cautions: Use cautiously in

• Cardiovascular disease
• Hepatic impairment
• Patients <2 yrs
• Geriatric population

Periactin interacts with :

	Aricept
	Aricept ODT
	Donepezil
	Exelon
	Galantamine
	Razadyne
	Razadyne ER
	Rivastigmine

Pregnancy Category:B

Breastfeeding: Contraindicated; should not be used in pregnancy as it may interfere with lactation, particularly when used in combination with a sympathomimetic or if lactation is not well established. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 21 January 2011).Because of the potential for serious adverse reactions in nursing infants from cyproheptadine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

• HEMA: Agranulocytosis, thrombocytopenia
• CNS: Drowsiness, excitation, headache, fatigue
• EENT: Blurred vision
• CV: Arrhythmias, hypotension, palpitations
• GI: Dry mouth, constipation, nausea, vomiting, abdominal pain, diarrhea
• GU: Hesitancy, urinary retention
• DERM: Photosensitivity, rashes, urticaria
• RESP: Thick sputum
• MISC: Weight gain, increased appetite

• Antihistaminic and antiserotonergic agent; antagonizes the effects of histamine at H-receptor sites, also blocks the effects of serotonin, which may result in increased appetite
• Well absorbed following oral administration
• Metabolized by liver
• Renally excreted (40%); feces (2-20%)
• Half-life: Unknown

US Trade Name(s)

• Only generic available

US Availability

cyproheptadine (generic)

• TABS: 4 mg
• SYRUP: 2 mg/5 mL

Canadian Trade Name(s)

• Only generic available

Canadian Availability

cyproheptadine (generic)

• TABS: 4 mg
• SYRUP: 2 mg/5 mL

UK Trade Name(s)

• Periactin

UK Availability

Periactin

• TABS: 4 mg

Australian Trade Name(s)

• Periactin

Australian Availability

Periactin

• TABS: 4 mg

[Outline]

ENT

Antihistamines

Allergy & Immunology

Antihistamines

Pricing data from www.DrugStore.com in U.S.A.

• Cyproheptadine HCl 2 MG/5ML SYRP [Bottle] (ACTAVIS MID ATLANTIC)
  120 5ml = $24.38
  360 5ml = $50.02

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

• Cyproheptadine hydrochloride 4 MG Oral Tablet (Cypress Pharmaceutical, Inc.)
• Cyproheptadine hydrochloride 4 MG Oral Tablet (NCS HealthCare of KY, Inc dba Vangard Labs)
• Cyproheptadine hydrochloride 4 MG Oral Tablet (Par Pharmaceutical Inc.)
• Cyproheptadine hydrochloride 4 MG Oral Tablet (Rising Pharmaceuticals Inc)
• Cyproheptadine hydrochloride 4 MG Oral Tablet (State of Florida DOH Central Pharmacy)
• Cyproheptadine hydrochloride 4 MG Oral Tablet (TEVA Pharmaceuticals USA Inc)