section name header

Interacting Drugs

OBJECT DRUGS

PRECIPITANT DRUGS

Calcium Channel Blockers:


Comment:

Ivabradine is a CYP3A4 substrate, and CYP3A4 inhibitors such as diltiazem or verapamil may increase the risk of toxicity. In addition to increasing ivabradine plasma concentrations, the negative inotropic effect of diltiazem and verapamil may add to that of ivabradine, increasing the risk of bradycardia.


Class 2: Use Only if Benefit Felt to Outweigh Risk