Adult Dosing

Bronchospasm

• 0.4-0.6% INH, 2 to 3 puffs every 3-4 hours
• MAX: 12 puffs per day

Acut Asthma [Non-FDA Approved]

• MDI: 2-3 puffs q 3-4 hrs; Max: 12 puffs/day
• Soln for INH: 0.2-0.3 Ml OF 5% Soln in 2.5 mL NS

Pediatric Dosing

• Safety and effectiveness in pediatric patients <12 yrs have not been established

Bronchospasm >12yo

• 0.4-0.6% INH, 2 to 3 puffs every 3-4 hours
• MAX: 12 puffs per day

[Outline]

• Adult Dosing
• Pediatric Dosing

• Bronchodilator for bronchial asthma
• Bronchospasm occurring in association with bronchitis and emphysema

• Hypersensitivity to any of the ingredients of the product
• Cardiac arrhythmias associated with tachycardia

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Avoid excessive use of adrenergic aerosols as it may be potential dangerous
• Paradoxical bronchoconstriction, cardiac arrest and life-threatening have been occurred during excessive use of metaproterenol sulfate as with other sympathomimetic inhalation preparations
• Allow sufficient interval of time to elapse prior to administration of another sympathomimetic agent such as epinephrine or isoproterenol

Cautions: Use cautiously in

• Hypertension
• Coronary artery disease
• CHF
• Hyperthyroidism
• Diabetes
• Hypersensitivity to sympathomimetic amines

Pregnancy Category:C

Breastfeeding: Safety unknown; no published literature exist on the use of metaproterenol by oral or by inhalation during lactation, data from the related drug, terbutaline, indicate that very less amount of drug is excreted into breastmilk. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 30 May 2011. Manufacturer advises caution while administering to nursing women.

• NEURO: Nervousness, tremor, palpitations
• GI: Nausea
• CV: Hypertension, Cardiac arrest, tachycardia
• DERM: Flushing
• RESP: Paradoxical bronchospasm

• Sympathomimetic; it activates adenyl cyclase enzyme which catalyze the conversion of ATP to c-AMP. Relaxes bronchial smooth muscle through beta-2 receptor stimulation
• Metabolized by liver
• Excreted in urine (40%) [Based on data from oral route]
• Half life: Unknown

US Trade Name(s)

• Only generic available

US Availability

metaproterenol (generic)

• SOLN for INH: 0.4%
• SOLN for INH: 0.6%

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Pulmonary

Bronchodilators

Beta Agonists (Inhaled)

Allergy & Immunology

Bronchodilators

Beta Agonists (Inhaled)