See Supplemental Patient Information
- Not indicated in fredrickson type I, III, IV and V dyslipidemias
- If coadministered with bile acid sequestrants, give ezetimibe either
2 hours before or 4 hours after the bile acid sequestrant - Monitor liver function initially and then as recommended for the statin (if given with a statin)
- It should be used in conjunction with standard cholesterol-lowering diet
- Persistent elevations of hepatic transaminases can occur when added to a statin. Monitor hepatic transaminases periodically. If ALT or AST 3 times ULN persist, consider withdrawal of either statin or ezetimibe
- Rare cases of rhabdomylosis/myopathy with acute renal failure have been reported when a statin is used in combination with ezetimibe; withhold temporarily in patients with acute serious condition suggestive of myopathy or in patients with predisposition to development of renal failure
Cautions: Use cautiously in
- Hepatic impairment
- Co-administration of fibrates other than fenofibrate (safety not established)
- Concomitant cholestyramine
Supplemental Patient Information
- Instruct patient to notify physican of any unexplained muscle pain, tenderness, weakness, or any other unusual feelings
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