Adult Dosing
Partial onset seizures adjunctive Therapy
Adults >16 yrs
- TABS
- Initial dose: 500 mg PO bid
- Titrate dose: Increase 1000 mg/day PO q2 wk
- Max: 3000 mg/day
- Extended Release TABS
- Initial dose: 1,000 mg PO Daily
- Titrate dose: increase 1,000 mg/day PO q2 wk
- Max: 3,000 mg/day
Juvenile myoclonic epilepsy adjunctive Therapy
Adults >12 yrs
- TABS
- Initial dose: 500 mg PO bid
- Titrate dose: Increase 1000 mg/day PO q2 wk
- Max: 3000 mg/day
Primary generalized tonic-clonic seizures adjunctive Therapy
Adults >16 yrs
- TABS
- Initial dose: 500 mg PO bid
- Titrate dose: Increase 1000 mg/day PO q2 wk
- Max: 3000 mg/day
Pediatric Dosing
Partial onset seizures adjunctive Therapy
Child (4 to <16 yrs)
- TABS
- Initial dose: 20 mg/kg/day PO div bid
- Titrate dose: increase 20 mg/kg/day PO q2 wk
- Max: 60 mg/kg/day, 3000 mg/day
Note:
- Patients with body weight
20 kg should be dosed with oral solution
Primary generalized tonic-clonic seizures adjunctive Therapy
Child (4 to <16 yrs)
- TABS
- Initial dose: 20 mg/kg/day PO div bid
- Titrate dose: increase 20 mg/kg/day PO q2 wk
- Max: 60 mg/kg/day, 3000 mg/day
[Outline]
Adult Renal Dose Adjustment (Based on CrCl)
- > 80 mL/min: 500-1500 mg PO bid
- 50-80 mL/min: 500-1,000 mg PO bid
- 30-50 mL/min: 250-750 mg PO bid
- < 30 mL/min: 250-750 mg PO bid
- ESRD patients using dialysis: 500-1,000 mg PO Daily; supplemental dose: 250-500 mg following dialysis
Hepatic Dose Adjustment
- Hepatic impairment: No dose adjustments
See Supplemental Patient Information
- Incidences of partial seizures, myoclonic seizures and primary generalized tonic-clonic epilepsy have been reported with the therapy
- Monitor hematologic abnormalities during therapy as cases of decreased hemoglobin or hematocrit have been reported
- Antiepileptic drugs, including levetiracetam, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication
- Epilepsy and many other illnesses for which antiepileptic drugs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior
- Carefully weigh risk vs benefit and observe all patients for clinical worsening, suicidality or unusual changes in behavior; advise family and caregivers for need of close supervision
- It is recommended to withdraw the drug slowly to prevent withdrawal seizures
Cautions: Use cautiously in
Supplemental Patient Information
- Carefully weigh risk vs benefit and observe all patients for clinical worsening, suicidality or unusual changes in behavior; advise family and caregivers for need of close supervision
Pregnancy Category:C
Breastfeeding: Excreted in small amounts in breast milk; hence would not be expected to cause any adverse effects in breastfed infants especially if the infant is older than 2 months. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 01 February 2011). According to manufacturer data, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Pricing data from www.DrugStore.com in U.S.A.
- Levetiracetam 1000 MG TABS [Bottle] (LUPIN PHARMACEUTICALS)
60 mg = $243.99
180 mg = $699.97 - Keppra XR 500 MG TB24 [Bottle] (UCB PHARMA)
60 mg = $263.98
180 mg = $752 - Levetiracetam 750 MG TABS [Bottle] (LUPIN PHARMACEUTICALS)
60 mg = $61.99
120 mg = $111.97 - Keppra 250 MG TABS [Bottle] (UCB PHARMA)
10 mg = $56.99
30 mg = $144.97 - Keppra XR 750 MG TB24 [Bottle] (UCB PHARMA)
60 mg = $410.97
180 mg = $1199.93 - Keppra 750 MG TABS [Bottle] (UCB PHARMA)
30 mg = $215
90 mg = $623.99 - Keppra 500 MG TABS [Bottle] (UCB PHARMA)
30 mg = $162.99
90 mg = $469.95 - Keppra 1000 MG TABS [Bottle] (UCB PHARMA)
60 mg = $643.02
180 mg = $1906.88 - Keppra 100 MG/ML SOLN [Bottle] (UCB PHARMA)
473 ml = $437.98
1419 ml = $1306.04
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
