Adult Dosing
Opioid-induced constipation
- < 38 kg (<84 lbs): 0.15 mg/kg SC every other day; Max: 1 dose/24 hrs
- 38 to < 62 kgs (84 to < 136 lbs): 8 mg SC every other day; Max: 1 dose/24 hrs
- 62 to 114 kgs (136 to 251 lbs): 12 mg SC every other day; Max: 1 dose/24 hrs
- >114 kgs (>251 lbs): 0.15 mg/kg SC every other day; Max: 1 dose/24 hrs
Pediatric Dosing
- Safety and effectiveness in pediatric patients have not been established
Renal Dose Adjustment (Based on CrCl )
- Mild to moderate impairment: No dose adjustments
- Severe impairment (CrCl < 30 mL/min): Decrease dose by 50%
Hepatic Dose Adjustment
- Mild to moderate impairment (Child Pugh Class A/B): No dose adjustments
- Severe impairment (Child Pugh Class C): Dose adjustments not defined
See Supplemental Patient Information
- Discontinue the therapy if severe of persistence diarrhea occurs during treatment
- GI perforation associated with localized or diffuse reduction of structural integrity in the wall of the GI tract has been reported in advanced illness patients. Use cautiously in patients with known or suspected lesions of the GI tract
- Discontinue therapy and inform physician if they develop severe, persistent, and/or worsening abdominal symptoms
Cautions: Use cautiously in
- Renal impairment
- GI lesions
Supplemental Patient Information
- Stop the therapy if they experience severe or persistent diarrhea
Pregnancy Category:B
Breastfeeding: Safety unknown; As per manufacture data, it is excreted in breast milk of lactating rats, no data is available whether it is excreted in human milk or not. Caution advises when administered to a nursing woman.
