Adult Dosing
Pediatric Dosing
Prevention of rotavirus gastroenteritis
RotaTeq
- Child 6-32 wks: 2 mL PO x 3 doses. Administer first dose to infants beginning at 6 to 12 weeks of age, with the subsequent doses administered at 4- to 10-wk intervals. The third dose should not be given after 32 weeks of age.
Rotarix
- Child 6-24 wks: 1 mL PO x 2 doses. Administer first dose to infants beginning at 6 wks of age. Administer second dose after an interval of at least 4 wks and prior to 24 wks of age.
[Outline]
- Delay the administration of rotavirus vaccine in infants suffering from acute diarrhea or vomiting as safety and effectiveness of rotavirus vaccine in infants with chronic gastrointestinal disorders have not been evaluated
- Shedding of rotavirus in stool occurs after vaccination with peak excretion occurring around day 7 after dose 1, leading to transmission of live vaccine virus to non-vaccinated contacts
Cautions: Use cautiously in
- History of gastrointestinal disorders
- Acute gastrointestinal illness
- Chronic diarrhea
- Failure to thrive
- History of congenital abdominal disorders
- History of abdominal surgery
- History of intussusception
- Blood dyscrasias
- Leukemia
- Lymphomas
- Malignant neoplasm affecting the bone marrow or lymphatic system
- Received a blood transfusion or blood products, including immunoglobulins within 42 days
- Concomitant immunosuppressants
- HIV infection
- Primary and acquired immunodeficiency states
- Hypogammaglobulinemic
- Dysgammaglobulinemic
- Cellular immune deficiencies
Pregnancy Category:C
Breastfeeding: Rotavirus vaccines are used only in infants and not in women of childbearing age. Breastfeeding protects infants against acute gastroenteritis caused by rotavirus, however can affect the immune response of an infant to rotavirus vaccines depending on the maternal anti-rotavirus antibody titer. Withholding breastfeeding for up to 2 hours before and after vaccine administration would likely minimize the interference based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 18 Jan 2011).
