OBJECT DRUGS

• Deferasirox (Exjade)

PRECIPITANT DRUGS

Absorption Inhibitors:

• Aluminum Antacids
• Cholestyramine (Questran, etc.)
• Colesevelam (WelChol)
• Colestipol (Colestid)

Comment:

Theoretically, the absorption of deferasirox may be reduced by agents containing aluminum. Cholestyramine moderately reduces deferasirox absorption, and other bile acid sequestrants probably have a similar effect.

Class 3: Assess Risk & Take Action if Necessary

• Circumvent/Minimize: If combined therapy is necessary, give the deferasirox at least 2 to 4 hours before or 6 hours after the absorption inhibitor to minimize the interaction.
• Monitor: Watch for reduced deferasirox efficacy in patients taking absorption inhibitors.