Adult Dosing
Dual amlodipine/atorvastatin treatment
- 1 tab PO qd. Max: PO 10 mg/80 mg/day
Note: Refer individual drug for dosing per specific indication
Pediatric Dosing
Dual amlodipine/atorvastatin treatment
10yrs
- 1 tab PO qd. Max PO 5 mg/20 mg/day
- Safety and effectiveness in pre-pubertal patients or pediatrics <10 yrs of age have not been established
Note: Refer individual drugs for dosing per specific indication
[Outline]
See Supplemental Patient Information
- Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have occurred; closely monitor skeletal muscle effects in patients with renal impairment
- Myopathy with increase in creatine phosphokinase (CPK) values >10 times ULN have occurred; avoid concomitant use with cyclosporine and strong CYP3A4 inhibitors
- Discontinue drug on occurrence of elevated CPK levels or myopathy is diagnosed or suspected
- Weigh the potential benefits and risks if considering combined therapy with fibric acid derivatives, erythromycin, clarithromycin, a combination of ritonavir plus saquinavir or lopinavir plus ritonavir, immunosuppressive drugs, azole antifungals, or lipid-modifying doses of niacin
- Carefully monitor patients during the initial months of therapy and during any periods of upward dosage titration of either drug for any signs or symptoms of muscle pain, tenderness, or weakness
- Consider lower initial and maintenance doses of atorvastatin when taken concomitantly with drugs that induce interactions
- Periodically perform creatine phosphokinase (CPK)
- Temporarily suspend or discontinue this drug in patients with an acute, serious condition suggestive of a myopathy or having a risk factor predisposing to the development of renal failure secondary to rhabdomyolysis
- Immune-mediated necrotizing myopathy (IMNM) characterized by proximal muscle weakness and elevated serum creatine kinase has been reported with statin use, and may persist despite discontinuation of statin treatment
- On occurrence of persistent elevations (>3 times the upper limit of normal [ULN]) in serum transaminases consider reduction of dose or withdrawal of this drug
- Perform liver function tests prior to and at 12 weeks following initiation of therapy and any elevation of dose, and semiannually thereafter
- Monitor patients with increased transaminase levels until the abnormalities are resolved
- On starting or increasing the dose of amlodipine worsening of angina and acute myocardial infarction may occur specifically in patients with severe obstructive coronary artery disease
- Symptomatic hypotension may occur in patients with severe aortic stenosis
- Does not protect against the dangers of abrupt beta-blocker withdrawal
- Might interfere with adrenal and/or gonadal steroid production
- Monitor patients receiving the combination of statins and fibrates for signs of myopathy
- Monitor BP at baseline, then periodically
- Can induce CNS toxicity
Cautions: Use cautiously in:
- Renal impairment
- Hepatic impairment
- Severe aortic stenosis
- CHF
- Severe CAD
- Alcohol abuse
- Recent Stroke
- TIA
- Concomitant use with drugs lowering the levels or activity of endogenous steroid hormones
Supplemental Patient Information
- Advise patients to report promptly on occurrence of unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever
Pregnancy Category:X
Breastfeeding: Possibly unsafe; Prefer an alternative drug during breastfeeding as appropriate literature on the use of amlodipine is unavailable. Data on atorvastatin during breastfeeding is not published. Disrupts infant's lipid metabolism; avoid use during breastfeeding. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 3 December 2010). Unknown whether the amlodipine/atorvastatin is excreted in human milk. Another drug in this class is excreted in human milk. Statins have potential to cause serious adverse reactions in nursing infants. Manufacturer advises to discontinue nursing.
US Trade Name(s)
US Availability
amlodipine/atorvastatin (generic)
- TABS:
- 2.5mg/10 mg
- 2.5 mg/20 mg
- 2.5 mg/40 mg
- 5 mg/10 mg
- 5 mg/20 mg
- 5 mg/40 mg
- 5 mg/80 mg
- 10 mg/10 mg
- 10 mg/20 mg
- 10 mg/40 mg
- 10 mg/80 mg
Caduet (amlodipine/atorvastatin)
- TABS:
- 5 mg/10 mg
- 5 mg/20 mg
- 5 mg/40 mg
- 5 mg/80 mg
- 10 mg/10 mg
- 10 mg/20 mg
- 10 mg/40 mg
- 10 mg/80 mg
- 2.5mg/10 mg
- 2.5 mg/20 mg
- 2.5 mg/40 mg
Canadian Trade Name(s)
Canadian Availability
Caduet (amlodipine/atorvastatin )
- TABS:
- 5 mg/10 mg
- 5 mg/20 mg
- 5 mg/40 mg
- 5 mg/80 mg
- 10 mg/10 mg
- 10 mg/20 mg
- 10 mg/40 mg
- 10 mg/80 mg
UK Trade Name(s)
UK Availability
Australian Trade Name(s)
Australian Availability
Caduet (amlodipine/atorvastatin )
- TABS:
- 5 mg/10 mg
- 5 mg/20 mg
- 5 mg/40 mg
- 5 mg/80 mg
- 10 mg/10 mg
- 10 mg/20 mg
- 10 mg/40 mg
- 10 mg/80 mg
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Caduet 2.5-20 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $226
90 mg = $635.99 - Caduet 5-10 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $162.99
90 mg = $458.96 - Caduet 10-40 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $227.98
90 mg = $651.99 - Amlodipine-Atorvastatin 5-20 MG TABS [Bottle] (RANBAXY PHARMACEUTICALS)
30 mg = $169.99
90 mg = $479.95 - Amlodipine-Atorvastatin 10-10 MG TABS [Bottle] (RANBAXY PHARMACEUTICALS)
30 mg = $140
90 mg = $395.96 - Caduet 10-10 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $167.98
90 mg = $474.95 - Caduet 2.5-40 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $227.98
90 mg = $639.99 - Caduet 10-80 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $227.89
90 mg = $620.05 - Caduet 10-20 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $226.99
90 mg = $654.96 - Caduet 5-40 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $218
90 mg = $621.98 - Amlodipine-Atorvastatin 5-40 MG TABS [Bottle] (RANBAXY PHARMACEUTICALS)
30 mg = $180
90 mg = $479.95 - Caduet 5-20 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $224
90 mg = $636.95 - Amlodipine-Atorvastatin 10-40 MG TABS [Bottle] (RANBAXY PHARMACEUTICALS)
30 mg = $159.98
90 mg = $459.98 - Amlodipine-Atorvastatin 10-20 MG TABS [Bottle] (RANBAXY PHARMACEUTICALS)
30 mg = $169.99
90 mg = $479.95 - Amlodipine-Atorvastatin 5-10 MG TABS [Bottle] (RANBAXY PHARMACEUTICALS)
30 mg = $140
90 mg = $395.96 - Caduet 5-80 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $227.98
90 mg = $650.96 - Caduet 2.5-10 MG TABS [Bottle] (PFIZER U.S.)
30 mg = $162.45
90 mg = $470.56
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.