Adult Dosing

Prophylaxis of Thromboembolism after Cardiac Valve Replacement

• 75-100 mg PO qid, as an adjunct to warfarin or aspirin

Pediatric Dosing

• Safety and effectiveness in the pediatric population have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Adjunctive treatment to reduce the risk of blood clots after heart valve replacement

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: Use with caution, dose adjustments not defined

• Dipyridamole has a vasodilatory effect, hence can aggravate chest pain in patients with underlying coronary artery disease. Use cautiously in these patients
• Dipyridamole can cause elevation of hepatic enzymes and hepatic failure
• Dipyridamole produce peripheral vasodilation and can lead to hypotension, use cautiously in patients with hypotension

Cautions: Use cautiously in

• Hepatic impairment
• Coronary artery diseases
• Hypotension

Pregnancy Category:B

Breastfeeding: As dipyridamole is excreted in human milk, manufacturer advises caution while administering to nursing woman.

• CNS: Dizziness, headache
• CV: Hypotension, chest pain, angina pectoris
• GI: Liver dysfunction, elevated hepatic enzymes, abdominal distress, diarrhea, vomiting
• DERM: Rash, flushing, pruritus

• Platelet aggregation inhibitor; inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. Also increase the intraplatelet concentration of cAMP by directly stimulating the release of prostacyclin, thus further inhibiting platelet aggregation
• Metabolized by liver
• Excreted in bile
• Half-life: 10 hrs

US Trade Name(s)

• Persantine

US Availability

dipyridamole (generic)

• TABS: 25, 50, 75 mg

Persantine

• TABS: 25, 50, 75 mg

Canadian Trade Name(s)

• Persantine
• Nova-Dipiradol

Canadian Availability

dipyridamole (generic)

• TABS: 25, 50, 75 mg

Nova-Dipiradol

• TABS: 25, 50, 75, 100 mg

Persantine

• TABS: 50, 75 mg

UK Trade Name(s)

• Persantine
• Persantin Retard

UK Availability

dipyridamole (generic)

• TABS: 25, 100 mg
• SUSP: 50 mg/5 mL

Persantine

• TABS: 25, 100 mg

Persantine Retard

• ECAPS: 200 mg

Australian Trade Name(s)

• Persantine
• Persantine SR

Australian Availability

Persantine

• TABS: 100 mg

Persantine SR

• ECAPS: 200 mg

[Outline]

Hematology/Oncology

Antiplatelet Agents

Platelet Aggregation Inhibitors

Cardiovascular

Antiplatelet Agents

Platelet Aggregation Inhibitors

Pricing data from www.DrugStore.com in U.S.A.

• Persantine 50 MG TABS [Bottle] (BOEHRINGER INGELHEIM)
  100 mg = $139.99
  300 mg = $399.95
• Dipyridamole 50 MG TABS [Bottle] (ZYDUS PHARMACEUTICALS (USA))
  90 mg = $57.99
  270 mg = $153.97
• Persantine 25 MG TABS [Bottle] (BOEHRINGER INGELHEIM)
  100 mg = $85.99
  300 mg = $235.98
• Persantine 75 MG TABS [Bottle] (BOEHRINGER INGELHEIM)
  100 mg = $169.99
  300 mg = $487.97

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

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• Dipyridamole 50 MG Oral Tablet (Barr Laboratories, Inc.)
• Dipyridamole 50 MG Oral Tablet (Cadila Healthcare Limited)
• Dipyridamole 50 MG Oral Tablet (Glenmark Generics Inc., USA)
• Dipyridamole 50 MG Oral Tablet (Lannett Company, Inc.)
• Dipyridamole 50 MG Oral Tablet (Physicians Total Care, Inc.)
• Dipyridamole 50 MG Oral Tablet (Rising Pharmaceuticals, Inc.)
• Dipyridamole 50 MG Oral Tablet (Zydus Pharmaceuticals (USA) Inc.)
• Dipyridamole 75 MG Oral Tablet (AvKARE, Inc.)
• Dipyridamole 75 MG Oral Tablet (BARR LABORATORIES, INC.)
• Dipyridamole 75 MG Oral Tablet (Barr Laboratories, Inc.)
• Dipyridamole 75 MG Oral Tablet (Cadila Healthcare Limited)
• Dipyridamole 75 MG Oral Tablet (Glenmark Generics Inc., USA)
• Dipyridamole 75 MG Oral Tablet (Lannett Company, Inc.)
• Dipyridamole 75 MG Oral Tablet (Physicians Total Care, Inc.)
• Dipyridamole 75 MG Oral Tablet (Rising Pharmaceuticals, Inc.)
• Dipyridamole 75 MG Oral Tablet (Zydus Pharmaceuticals (USA) Inc.)
• Persantine 25 MG Oral Tablet (Boehringer Ingelheim Pharmaceuticals Inc.)
• Persantine 50 MG Oral Tablet (Boehringer Ingelheim Pharmaceuticals Inc.)
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