Adult Dosing

Prevention and relief of postoperative ocular inflammation

• Instill 1-2 gtt into the conjunctival sac of the affected eye(s) qid
• Start 24 hrs after surgery and continue for the first 2 wks of the postoperative period

Anterior uveitis

• Instill 1-2 gtt into the conjunctival sac of the affected eye(s) q1 hr x 7 days during waking hours, then 1 gtt q2 hrs x 7 days during waking hours and taper the dose until uveitis is resolved

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

• Treatment of postoperative inflammation following ocular surgery and in the treatment of anterior uveitis

• Hypersensitivity to any of the ingredients of the product
• Epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella and many other viral diseases of the cornea and conjunctiva
• Mycobacterial infections of the eye
• Fungal diseases of the eye
• Acute purulent untreated infections, which may be masked or enhanced by the presence of the steroid

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Rimexolone is for topical ophthalmic use only and not for injection
• Use cautiously in the treatment of herpes simplex infection; monitor the patient with frequent slit-lamp examinations
• Prolonged use may result in ocular hypertension or glaucoma, damage to the optic nerve, defects in visual acuity and visual fields, and posterior subcapsular cataract formation. Monitor IOP in patients receiving the drug for 10 days
• Prolonged therapy may result in secondary ocular infections due to suppression of host response
• Acute purulent infections of the eye may be masked or exacerbated by the presence of steroid medication
• In diseases causing thinning of the cornea or sclera, chronic use of topical steroids may lead to perforation
• Long-term local steroid application is associated with the development of fungal infections of the cornea. Consider fungal invasion in any persistent corneal ulceration where a steroid has been used or is in use
• Advise patients to avoid touching the dropper tip to eyelids or to any other surface in order to prevent contamination
• Initial prescription and renewal of the drug beyond 14 days should be made by a physician only after examining the patient with the help of slit-lamp biomicroscopy and where appropriate, fluorescein staining
• Reevaluate the patient if signs and symptoms do not improve after 2 days of treatment

Use cautiously in

• Glaucoma
• Corneal abrasion

Supplemental Patient Information

• Advise patients not to touch the dropper tip to eyelids or to any other surface in order to prevent contamination

Pregnancy Category:C

Breastfeeding: Safety unknown. As per manufacturer's data, caution should be exercised when administered to nursing women. A decision should be made whether to discontinue nursing or to discontinue therapy, analyzing the importance of the drug to the mother.

• EENT: Increased IOP, corneal thinning, optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection, blurred vision, burning, discharge, discomfort, ocular pain, hyperemia, rhinitis, pharyngitis, vision loss, foreign body sensation
• DERM: Pruritus
• CNS: Headache
• CV: Hypotension
• GI: Taste perversion

• Corticosteroid; suppresses the inflammatory response to a variety of inciting agents of a mechanical, chemical, or immunological nature
• Metabolized in the liver
• Excreted in feces [Data based on IV administration]
• Half-life: 1-2 hrs

US Trade Name(s)

• Vexol

US Availability

Vexol

• OPH SUSP: 1%

Canadian Trade Name(s)

• Vexol

Canadian Availability

Vexol

• OPH SUSP: 1%

UK Trade Name(s)

• Vexol

UK Availability

Vexol

• OPH SUSP: 1%

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

Ophthalmic

Ophthalmic Steroids

Pricing data from www.DrugStore.com in U.S.A.

• Vexol 1 % SUSP [Bottle] (ALCON VISION)
  5 % = $55.61
  15 % = $141.75
• Vexol 1 % SUSP [Bottle] (ALCON VISION)
  10 % = $81.77
  30 % = $224.58

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.