Adult Dosing

Anxiety disorders

• Initial: 7.5 mg PO bid
• Titrate: Increase in increments of 5 mg/day q2-3 days
• Usual: 20-30 mg/day in divided doses; Max: 60 mg/day

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Management of anxiety disorders or the short-term relief of the symptoms of anxiety

• Hypersensitivity to any of the ingredients of the product
• Concomitant monoamine oxidase inhibitor (MAOI)

• N/A

Renal Dose Adjustment

• Renal impairment: Use with caution; not recommended in patients with severe renal disease

Hepatic Dose Adjustment

• Hepatic impairment: Use with caution; not recommended in patients with severe hepatic disease

See Supplemental Patient Information

• This drug do not have established antipsychotic activity and hence, it should not be employed in lieu of appropriate antipsychotic treatment
• Low potential for cognitive or motor impairment; until effects on patient known, patients should be warned to use caution when performing tasks which require mental alertness (eg, operating machinery or driving)
• Restlessness syndrome have occurred in some patients; may be attributable to buspirone's antagonism of central dopamine receptors; monitor for signs of any dopamine-related movement disorders (i.e, represent akathisia)
• Buspirone does not exhibit cross-tolerance with benzodiazepines or other sedative/hypnotic agents; if substituting buspirone for any of these agents, gradually withdraw the drug(s) before initiating buspirone

Cautions: Use cautiously in

• Renal impairment
• Hepatic impairment
• Concomitant use with Grapefruit Juice

Supplemental Patient Information

• Instruct patients to take buspirone consistently, either always with or always without food
• Instruct patients not to drive a car or operate potentially dangerous machinery until they experience how this medication affects them
• Advise patients to avoid consumption of grapefruit juice in large amount

BuSpar interacts with :

	Agenerase
	Akne-mycin
	Amiodarone
	Amprenavir
	Aprepitant
	Atazanavir
	Biaxin
	Biaxin XL
	Boceprevir
	Calan
	Calan SR
	Cardizem
	Cardizem CD
	Cardizem LA
	Cartia XT
	Ceritinib
	Cetraxal
	Ciloxan
	Cipro
	Cipro IV
	Cipro XR
	Ciprofloxacin
	Clarithromycin
	Cobicistat
	Conivaptan
	Cordarone
	Covera-HS
	Crixivan
	Cyclosporine
	Darunavir
	Delavirdine
	Diflucan
	Dilacor XR
	Dilt-CD
	Diltiazem
	Diltzac
	Dronedarone
	E-Mycin
	E.E.S.
	Emend
	Ery-Tab
	Eryc
	Erygel
	Eryped
	Erythra-Derm
	Erythro-statin
	Erythrocin
	Erythromycin
	Extina
	Fluconazole
	Fluvoxamine
	Gengraf
	Grapefruit
	Incivek
	Indinavir
	Invirase
	Isoptin
	Isoptin SR
	Itraconazole
	Juxtapid
	Ketek
	Ketoconazole
	Korlym
	Lomitapide
	Luvox
	Luvox CR
	Mifepristone
	Multaq
	Nefazodone
	Nelfinavir
	Neoral
	Nexterone
	Nizoral
	Nizoral A-D Shampoo
	Nizoral Shampoo
	Norvir
	Noxafil
	Onmel
	Pacerone
	PCE
	Pediamycin
	Posaconazole
	Prezista
	Proquin XR
	Quinupristin
	Rescriptor
	Restasis
	Reyataz
	Ritonavir
	Sandimmune
	Saquinavir
	Sporanox
	Stribild
	Synercid
	TAO
	Taztia XT
	Telaprevir
	Telithromycin
	Tiazac
	Troleandomycin
	Vaprisol
	Veralan
	Verapamil
	Verelan PM
	Vfend
	Victrelis
	Viracept
	Voriconazole
	Xolegel
	Zykadia

Pregnancy Category:B

Breastfeeding: Safety Unknown; excreted in the milk of rats; Because of the potential for possible serious adverse reactions in nursing infants a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

• CNS: Dizziness, nausea, headache, nervousness, lightheadedness, excitement, anger/hostility, confusion, depression, fatigue, insomnia, cerebrovascular accident
• CV: Tachycardia/palpitations, CHF, MI
• EENT: Blurred Vision
• GI: Nausea, dry Mouth, abdominal/gastric distress, diarrhea, constipation, vomiting
• MUSC: Musculoskeletal aches/pains
• PSYCHIATRY: Numbness, paresthesia, incoordination, tremor
• DERM: Skin Rash
• MISC: Weakness, sweating/clamminess

• Anxiolytic; exact mechanism of action is unknown. Thought to bind to serotonin and dopamine receptors in CNS, increasing dopamine metabolism and impulse formation
• Metabolized in liver; CYP450: 3A4 substrate
• Bioavailability: 90%
• Excreted in urine (29-63% as metabolite); feces (18-38% of the dose)
• Half-life: 2-3 hrs

US Trade Name(s)

• BuSpar

US Availability

buspirone (generic)

• TABS: 5, 7.5, 10, 15, 30 mg

BuSpar

• TABS: 5 mg

Canadian Trade Name(s)

• Only generic available

Canadian Availability

buspirone (generic)

• TABS: 5, 10 mg

UK Trade Name(s)

• BuSpar

UK Availability

buspirone (generic)

• TABS: 5, 10 mg

BuSpar

• TABS: 5, 10 mg

Australian Trade Name(s)

• BuSpar

Australian Availability

BuSpar

• TABS: 5, 10 mg

[Outline]

Psychiatric

Anxiolytics/Sedatives/Hypnotics

Miscellaneous Agents

Neurologic

Anxiolytics/Sedatives/Hypnotics

Miscellaneous Agents

Pricing data from www.DrugStore.com in U.S.A.

• BusPIRone HCl 30 MG TABS [Bottle] (MYLAN)
  30 mg = $50.99
  90 mg = $133.97
• BusPIRone HCl 7.5 MG TABS [Bottle] (PAR)
  60 mg = $99.57
  180 mg = $282.38
• BuSpar 30 MG TABS [Bottle] (B-M SQUIBB U.S. (PRIMARY CARE))
  30 mg = $158.07
  90 mg = $453.94

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

• BuSpar Dividose 15 MG Oral Tablet (Bristol-Myers Squibb)
• BuSpar Dividose 30 MG Oral Tablet (Bristol-Myers Squibb)
• Buspar 10 MG Oral Tablet (Bristol-Myers Squibb)
• Buspar 5 MG Oral Tablet (Bristol-Myers Squibb)
• Buspirone hydrochloride 10 MG (buspirone 9.1 MG) Oral Tablet (Dr. Reddy's Laboratories Ltd)
• Buspirone hydrochloride 10 MG (buspirone 9.1 MG) Oral Tablet (ETHEX)
• Buspirone hydrochloride 10 MG (buspirone 9.1 MG) Oral Tablet (IVAX Pharmaceuticals, Inc.)
• Buspirone hydrochloride 10 MG (buspirone 9.1 MG) Oral Tablet (Mylan Pharmaceuticals Inc.)
• Buspirone hydrochloride 10 MG (buspirone 9.1 MG) Oral Tablet (NCS HealthCare of KY, Inc dba Vangard Labs)
• Buspirone hydrochloride 10 MG (buspirone 9.1 MG) Oral Tablet (Par Pharmaceutical Inc)
• Buspirone hydrochloride 10 MG (buspirone 9.1 MG) Oral Tablet (Physicians Total Care, Inc.)
• Buspirone hydrochloride 10 MG (buspirone 9.1 MG) Oral Tablet (STAT RX USA LLC)
• Buspirone hydrochloride 10 MG (buspirone 9.1 MG) Oral Tablet (Watson Laboratories, Inc.)
• Buspirone hydrochloride 15 MG (buspirone 13.7 MG) Oral Tablet (Dr. Reddy's Laboratories Ltd)
• Buspirone hydrochloride 15 MG (buspirone 13.7 MG) Oral Tablet (ETHEX)
• Buspirone hydrochloride 15 MG (buspirone 13.7 MG) Oral Tablet (IVAX Pharmaceuticals, Inc.)
• Buspirone hydrochloride 15 MG (buspirone 13.7 MG) Oral Tablet (Major Pharmaceuticals)
• Buspirone hydrochloride 15 MG (buspirone 13.7 MG) Oral Tablet (Mylan Pharmaceuticals Inc.)
• Buspirone hydrochloride 15 MG (buspirone 13.7 MG) Oral Tablet (NCS HealthCare of KY, Inc dba Vangard Labs)
• Buspirone hydrochloride 15 MG (buspirone 13.7 MG) Oral Tablet (Par Pharmaceutical Inc)
• Buspirone hydrochloride 15 MG (buspirone 13.7 MG) Oral Tablet (Physicians Total Care, Inc.)
• Buspirone hydrochloride 15 MG (buspirone 13.7 MG) Oral Tablet (Watson Laboratories, Inc.)
• Buspirone hydrochloride 30 MG (buspirone 27.4 MG) Oral Tablet (Dr. Reddy's Laboratories Ltd)
• Buspirone hydrochloride 30 MG (buspirone 27.4 MG) Oral Tablet (Mylan Pharmaceuticals Inc.)
• Buspirone hydrochloride 30 MG (buspirone 27.4 MG) Oral Tablet (TEVA Pharmaceuticals USA Inc)
• Buspirone hydrochloride 5 MG (buspirone 4.6 MG) Oral Tablet (Dr. Reddy's Laboratories Ltd)
• Buspirone hydrochloride 5 MG (buspirone 4.6 MG) Oral Tablet (ETHEX)
• Buspirone hydrochloride 5 MG (buspirone 4.6 MG) Oral Tablet (IVAX Pharmaceuticals, Inc.)
• Buspirone hydrochloride 5 MG (buspirone 4.6 MG) Oral Tablet (Mylan Pharmaceuticals Inc.)
• Buspirone hydrochloride 5 MG (buspirone 4.6 MG) Oral Tablet (NCS HealthCare of KY, Inc dba Vangard Labs)
• Buspirone hydrochloride 5 MG (buspirone 4.6 MG) Oral Tablet (Par Pharmaceutical Inc)
• Buspirone hydrochloride 5 MG (buspirone 4.6 MG) Oral Tablet (Physicians Total Care, Inc.)
• Buspirone hydrochloride 5 MG (buspirone 4.6 MG) Oral Tablet (Watson Laboratories, Inc.)
• Buspirone hydrochloride 7.5 MG Oral Tablet (NCS HealthCare of KY, Inc dba Vangard Labs)
• Buspirone hydrochloride 7.5 MG Oral Tablet (Par Pharmaceutical Inc)