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Use and Dosing

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Hypertension

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[Outline]

Indications

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment

Hepatic Dose Adjustment

Warnings/Precautions

Cautions: Use cautiously in

Pregnancy/Breast Feeding

Pregnancy Category:C (first trimester) and D (second and third trimesters)

Breastfeeding: As low level of captopril is excreted in breastmilk, amount ingested by the infant is small and would not be expected to cause any adverse effects in breastfed infants. During lactation hydrochlorothiazide at a dose of 50 mg daily or less is acceptable. Intense diuresis with large doses may decrease breastmilk production. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 22 February 2011). As per manufacturer's data both captopril and hydrochlorothiazide are excreted in human milk. Because of the potential for serious adverse reactions from hydrochlorothiazide and captopril in nursing infants, a decision should be made whether to discontinue nursing or to discontinue captopril/hydrochlorothiazide taking into account the importance of the drug to the mother.

Adverse Reactions

Clinical Pharmacology

Captopril

Hydrochlorothiazide

Brands and Availability

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US Trade Name(s)

US Availability

captopril/hydrochlorothiazide (generic)

Capozide (captopril/hydrochlorothiazide)

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Canadian Trade Name(s)

Canadian Availability

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UK Trade Name(s)

UK Availability

Capozide LS (captopril/hydrochlorothiazide)

Capozide (captopril/hydrochlorothiazide)

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Australian Trade Name(s)

Australian Availability


[Outline]

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Classification

Cardiovascular

Antihypertensive Combinations

Pill