Adult Dosing

Irritable bowel syndrome, postoperative paralytic ileus

• 600 mg/day PO in divided doses
• 2(100mg) TABS PO tid or 200mg TABS tid

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment and relief of symptoms associated with the irritable bowel syndrome
• Postoperative paralytic ileus

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Prohibit use in pregnancy
• Safety and efficacy in pediatric patients <12 yrs have not been established

Use cautiously in:

• Pregnancy

Pregnancy Category: Unknown

Breastfeeding: Safety unknown; manufacturer advises to avoid use in pregnancy

• GI: Dry mouth, foul taste, diarrhea, dyspepsia, epigastric pain, nausea, constipation
• CNS: Drowsiness, fatigue, dizziness, hot/cold sensations, headache, anxiety
• DERM: Rash
• GU: Menstrual problems, painful enlargement of breast, urine retention
• EENT: Slight deafness

• Noncompetitive spasmolytic agent; exhibits moderate opiate receptor affinity, antiserotonin activity especially on 'M' receptors, regulates lowers gastrointestinal tract motility
• Metabolized by liver
• Excreted in urine
• Half life: 10-12 hrs

US Trade Name(s)

• N/A

US Availability

• N/A

Canadian Trade Name(s)

• Modulon

Canadian Availability

trimebutine (generic)

• TABS: 100, 200 mg

Modulon

• TABS: 200 mg

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Gastrointestinal

Anticholinergics/Antispasmodics (GI)