OBJECT DRUGS

• Dolutegravir (Tivicay)

PRECIPITANT DRUGS

Enzyme Inducers (UGT1A1):

• Efavirenz (Sustiva)
• Etravirine (Intelence)
• Rifampin (Rifadin, etc.)
• St. John's wort
• Tipranavir (Aptivus)

Comment:

Dolutegravir is a substrate of UGT1A1. Inducers of UGT1A1 may reduce dolutegravir plasma concentrations by over 50%. Loss of antiviral activity may occur.

Class 3: Assess Risk & Take Action if Necessary

• Monitor: If UGT1A1 inducers are coadministered with dolutegravir, consider increasing the dose of dolutegravir and monitor for reduced antiviral response.