Adult Dosing

Advanced postmenopausal breast cancer

• 1 mg PO Daily

Adjuvant therapy for early-stage breast cancer in postmenopausal women

• 1 mg PO Daily

Note:

• Anastrozole should be continued until tumor progression is evident, and can be taken with or without food

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer
• First-line treatment of postmenopausal women with hormone receptor-positive, hormone receptor unknown locally advanced or metastatic breast cancer
• Advanced breast cancer in postmenopausal women with progression following tamoxifen therapy
• Patients with ER-negative disease and who did not respond to tamoxifen therapy

• Hypersensitivity to any of the ingredients of the product
• Premenopausal women (safety not established)
• Pregnancy

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Mild to moderate: No dose adjustments

See Supplemental Patient Information

• In patient with pre-existing ischemic heart disease, increased incidences of ischemic cardiovascular events have been reported with anastrozole. Consider risk and benefits of therapy in patients with pre-existing ischemic heart disease
• Decrease in lumbar spine and total hip bone mineral density (BMD) compared to baseline has occurred in patient receiving anastrozole
• Patient receiving therapy have reported elevated serum cholesterol compared to patients receiving tamoxifen

Caution: Use cautiously in

• Ischemic heart diseases

Supplemental Patient Information

• Advise patient that anastrozole may cause fetal harm, avoid using in premenopausal women and in pregnancy
• Advise patient not to take anastrozole with tamoxifen therapy

Arimidex interacts with :

	Agenerase
	Akne-mycin
	Amiodarone
	Amprenavir
	Atazanavir
	Barbiturates
	Biaxin
	Biaxin XL
	Boceprevir
	Bosentan
	Calan
	Calan SR
	Carbamazepine
	Carbatrol
	Cardizem
	Cardizem CD
	Cardizem LA
	Cartia XT
	Ceritinib
	Cetraxal
	Ciloxan
	Cipro
	Cipro IV
	Cipro XR
	Ciprofloxacin
	Clarithromycin
	Cobicistat
	Conivaptan
	Cordarone
	Covera-HS
	Crixivan
	Cyclosporine
	Dabrafenib
	Darunavir
	Delavirdine
	Diflucan
	Dilacor XR
	Dilantin
	Dilantin Infatabs
	Dilantin-125
	Dilt-CD
	Diltiazem
	Diltzac
	Dronedarone
	E-Mycin
	E.E.S.
	Efavirenz
	Epitol
	Equetro
	Ery-Tab
	Eryc
	Erygel
	Eryped
	Erythra-Derm
	Erythro-statin
	Erythrocin
	Erythromycin
	Etravirine
	Extina
	Fluconazole
	Fluvoxamine
	Gengraf
	Gleevec
	Grapefruit
	Imatinib
	Incivek
	Indinavir
	INH
	Intelence
	Invirase
	Isoniazid
	Isoptin
	Isoptin SR
	Itraconazole
	Juxtapid
	Ketek
	Ketoconazole
	Korlym
	Lapatinib
	Lomitapide
	Lumacaftor
	Luvox
	Luvox CR
	Mifepristone
	Multaq
	Mycobutin
	Mysoline
	Nefazodone
	Nelfinavir
	Neoral
	Nevirapine
	Nexterone
	Nizoral
	Nizoral A-D Shampoo
	Nizoral Shampoo
	Norvir
	Noxafil
	Onmel
	Orkambi
	Oxcarbazepine
	Oxtellar XR
	Pacerone
	PCE
	Pediamycin
	Phenytek
	Phenytoin
	Posaconazole
	Prezista
	Priftin
	Primidone
	Proquin XR
	Quinupristin
	Rescriptor
	Restasis
	Reyataz
	Rifabutin
	Rifadin
	Rifampin
	Rifapentine
	Rimactane
	Ritonavir
	Sandimmune
	Saquinavir
	Sporanox
	St. John's wort
	Stribild
	Sustiva
	Synercid
	Tafinlar
	TAO
	Taztia XT
	Tegretol
	Tegretol XR
	Telaprevir
	Telithromycin
	Teril
	Tiazac
	Tracleer
	Trileptal
	Troleandomycin
	Tykerb
	Vaprisol
	Veralan
	Verapamil
	Verelan PM
	Vfend
	Victrelis
	Viracept
	Viramune
	Viramune XR
	Voriconazole
	Xolegel
	Zykadia

Pregnancy Category:X

Breastfeeding: It is unknown whether if anastrozole is excreted in human milk. Manufacturer advises decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

• CV: MI, stroke, angina, hypertension, vasodilation
• CNS: headache, insomnia, anxiety
• PSYCHIATRY: Depression, mood disturbances
• GI: Nausea, vomiting, abdominal pain, constipation, diarrhea, GI disturbance, anorexia, dyspepsia, dry mouth
• GU: Endometrial cancer, breast pain, vulvovaginitis, breast neoplasm, vaginal hemorrhage, vaginal discharge, tumor flare, leukorrhea, urinary tract infection
• HEMA: Thromboembolism, anemia, leukopenia, lymphedema
• METABOLIC: Hypercholesterolemia, increased alkaline phosphatase, weight gain
• DERM: Erythema multiforme, Stevens-Johnson syndrome, hot flashes, rash, edema, paresthesia, sweating, pruritus
• EENT: Cataracts, pharyngitis, rhinitis
• RESP: Dyspnea, cough, sinusitis, bronchitis
• MUSC: Fractures, osteoporosis, arthralgia, arthritis, bone pain, arthrosis, pelvic pain, joint disorder, myalgia
• MISC: Asthenia, pain, infection, accidental injury, chest pain, flu syndrome, cyst, neoplasm, carpal tunnel syndrome, malaise, menopausal flushing

• Aromatase inhibitor; inhibits aromatase thus decreasing serum and tumor concentration of estrogen, leading to a decreased tumor mass or delayed progression of tumor growth
• Metabolized in liver; CYP450, 1A2, 2C8/9, and 3A4
• Excreted in urine (10% unchanged) and feces
• Half-life: 50 hrs

US Trade Name(s)

• Arimidex

US Availability

anastrozole (generic)

• TABS: 1 mg

Arimidex

• TABS: 1 mg

Canadian Trade Name(s)

• Arimidex

Canadian Availability

Arimidex

• TABS: 1 mg

UK Trade Name(s)

• Arimidex

UK Availability

anastrozole (generic)

• TABS: 1 mg

Arimidex

• TABS: 1 mg

Australian Trade Name(s)

• Arimidex

Australian Availability

Arimidex

• TABS: 1 mg

[Outline]

Hematology/Oncology

Antineoplastics

Aromatase Inhibitor

Pricing data from www.DrugStore.com in U.S.A.

• Arimidex 1 MG TABS [Bottle] (ASTRAZENECA)
  30 mg = $458.97
  90 mg = $1313.01
• Anastrozole 1 MG TABS [Bottle] (ZYDUS PHARMACEUTICALS (USA))
  30 mg = $186.01
  60 mg = $359.96

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

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