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Interacting Drugs

OBJECT DRUGS

PRECIPITANT DRUGS

NSAIDs:


Comment:

Lithium toxicity has been reported with concurrent NSAID therapy, although the magnitude of the effect is highly variable from patient to patient. The lithium toxicity can be severe, and there are many case reports of lithium toxicity following initiation of NSAIDs. In an epidemiologic study ACE inhibitors and loop diuretics were associated with a substantial increase in the risk of hospitalization due to lithium toxicity, but an association with thiazide diuretics and NSAIDs was not found. It may be that only predisposed patients develop lithium toxicity from NSAIDs; for example only some patients manifest substantial reductions in renal function following use of NSAIDs.


Class 3: Assess Risk & Take Action if Necessary