Adult Dosing

Constipation

Rectal Suppository (SUPP: 80.7%, 82.5%, 2, 2.1 g, SUPP LIQ: 5.6 g)

• Insert 1 SUPP PR qd
• MAX: 1 SUPP/day

Note:

• Retain the suppository in rectum for at least 15 minutes

Pediatric Dosing

Constipation

2-5 yrs: Rectal Suppositories (SUPP: 80.7%, 82.5%, 1, 1.2 g; SUPP LIQ: 2.3 g)

• Insert 1 SUPP PR qd. MAX: 1 SUPP/day

>6 yrs: Rectal Suppositories (SUPP: 80.7%; 2, 2.1 g; SUPP LIQ: 5.6 g)

• Insert 1 SUPP PR qd. MAX: 1 SUPP/day

Note:

• Retain the SUPP in rectum for at least 15 minutes

• Relief of occasional constipation

• Hypersensitivity to any of the ingredients of the product
• Anuria
• Severe volume depletion
• Pulmonary edema

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined; caution advised

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined; caution advised

• Do not use for more than 1 wk unless directed by the physician
• Therapy may cause rectal discomfort or a burning sensation
• If the patient experiences rectal bleeding or fails to have a bowel movement after the laxative use, discontinue use and consult a physician
• Pregnant women or lactating mothers should consult their physician before use
• Advise patients not to use laxatives if they have abdominal pain, nausea, or vomiting
• Prior to use, advise patients to discuss if they have observed a sudden change in bowel habits that persist for over 2 weeks
• Do not use other laxatives concomitantly unless prescribed by the physician

Cautions: Use cautiously in

• Renal impairment
• Hepatic impairment

Pregnancy Category:C

Breastfeeding: Safety unknown.

• CNS: Headache
• GI: Diarrhea, nausea, rectal irritation, rectal pain, rectal bleeding, rectal discomfort or a burning sensation

• Laxative; promotes bowel evacuation by local irritation and hyperosmotic actions
• Metabolism: Liver
• Renally excreted
• Half-life: Unknown

US Trade Name(s)

• Colace Suppository for Adults and Children
• Colace Suppository for Infants and Children
• Fleet Child Glycerin Suppository
• Fleet Adult Glycerin Suppository
• Fleet Liquid Glycerin Suppository
• Pedia-Lax Glycerin Suppository
• Pedia-Lax Liquid Glycerin Suppository
• Sani-Supp Adult
• Sani-Supp Pediatric

US Availability

glycerin (generic)

• OTC SUPP: 80.7%
• OTC SUPP: 2 g

Colace Suppository for Adults and Children

• OTC SUPP: 2.1 g

Colace Suppository for Infants and Children

• OTC SUPP: 1.2 g

Fleet Child Glycerin Suppository

• OTC SUPP: 1 g

Fleet Adult Glycerin Suppository

• OTC SUPP: 2 g

Fleet Liquid Glycerin Suppository

• OTC SUPP LIQ: 5.6 g

Pedia-Lax Glycerin Suppository

• OTC SUPP: 1 g

Pedia-Lax Liquid Glycerin Suppository

• OTC SUPP LIQ: 2.3 g

Sani-Supp Adult

• OTC SUPP: 82.5%

Sani-Supp Pediatric

• OTC SUPP: 82.5%

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• Boots Constipation Relief Suppositories

UK Availability

glycerin (generic)

• SUPP: 4 g

Boots Constipation Relief Suppositories

• SUPP: 4 g

Australian Trade Name(s)

• Only generic available

Australian Availability

glycerin (generic)

• SUPP: 1, 2, 4 g

Gastrointestinal

Laxatives