Adult Dosing
Amenorrhea
- 5-10 mg IM Daily x 6 to 8 consecutive days
- Withdrawal bleeding can be expected 48-72 hrs after the last injection, followed by spontaneous normal cycles
Functional Uterine Bleeding
- 5-10 mg IM Daily x 6 days
- Bleeding is expected to cease within 6 days
- If estrogen is to be given, initiate progesterone after 2 weeks of estrogen therapy
- If menstrual flow begins during progesterone therapy, discontinue therapy
Pediatric Dosing
- Safety and effectiveness in pediatric patients have not been established
[Outline]
- Remain alert to earliest manifestations of thrombotic disorders (thrombophlebitis, cerebrovascular disorders, pulmonary embolism, and retinal thrombosis). Promptly discontinue treatment if any of these occur
- In case of sudden partial or complete loss of vision, or sudden onset of proptosis, diplopia or migraine, discontinue drug and perform required examination. Drug should be withdrawn if papilledema or retinal vascular lesions is seen in examination
- A physical examination including special reference to breast and pelvic organs, as well as a Papanicolaou smear is recommended prior to treatment
- Fluid retention has been reported with the use of progesterone. Carefully observe patients with conditions which might be influenced by fluid retention
- If breakthrough bleeding is observed, any nonfunctional causes should be taken into account, and appropriate diagnostic measures undertaken
- Carefully observe patients with a history of psychic depression. Discontinue therapy if depression recurs to a serious degree
- Patient age should not be a limiting factor, although treatment with progestin may mask the onset of the climacteric
- Pathologists should be notified of progestin therapy when relevant specimens are given for testing
- Adverse effects on carbohydrate and lipid metabolism may possibly occur with progestin therapy. These effects may be dose dependent
- Decreased glucose tolerance has been reported in a few patients receiving estrogen-progestin combination. Closely observe diabetic patients receiving such therapy
Cautions: Use cautiously in
- History of psychic depression
- Epilepsy
- Migraine
- Asthma
- Cardiac dysfunction
- Renal dysfunction
- Diabetes
Pregnancy Category:NR
Breastfeeding: Because of the low levels of progesterone in breastmilk, even with the high-dose products, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. Most studies indicate that progesterone is not detrimental to milk production or duration of nursing. No special precautions are required. This information is based upon Lactmed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 02 Dec 2013). Manufacturer advises caution.
