Adult Dosing
Candidemia, acute disseminated candidiasis, Candida peritonitis and abscesses
- 100 mg IV infusion over 1 hr qd x 10-47 days (mean treatment duration of 15 days)
Esophageal candidiasis
- 150 mg IV infusion over 1 hr qd x 10-30 days (mean treatment duration of 15 days)
Prophylaxis of Candida infections in HSCT recipients
- 50 mg IV infusion over 1 hr qd x 6-51 days (mean prophylaxis duration of 19 days)
Notes:- Should be reconstituted and diluted with 0.9% NaCl or 5% dextrose prior to infusion
- Flush the existing IV line with 0.9% NaCl injection prior to infusion of micafungin
- Do not mix or co-infuse with other drugs
Pediatric Dosing
- Safety and effectiveness in pediatric patients <4 months of age have not been established
Candidemia, acute disseminated candidiasis, Candida peritonitis and abscesses
- Children
4 mo and
30 kg - 2 mg/kg IV infusion over 1 hr qd
- Max: 100mg/day
- Children
4 mo and >30 kg - 2 mg/kg IV infusion over 1 hr qd
- Max: 100mg/day
Esophageal candidiasis
- Children
4 mo and
30 kg - 3 mg/kg IV infusion over 1 hr qd
- Children
4 mo and >30 kg - 2.5 mg/kg IV infusion over 1 hr qd
- Max: 100mg/day
Prophylaxis of Candida infections in HSCT recipients
- Children
4 mo and
30 kg - 1 mg/kg IV infusion over 1 hr qd
- Max: 50mg/day
- Children
4 mo and >30 kg - 1 mg/kg IV infusion over 1 hr qd
- Max: 50mg/day
Notes:- Should be reconstituted and diluted with 0.9% NaCl or 5% dextrose prior to infusion
- Flush the existing IV line with 0.9% NaCl injection prior to infusion of micafungin
- Do not mix or co-infuse with other drugs
- Administer concentrations >1.5 mg/mL via central catheter to minimize the risk of infusion reactions
[Outline]
Pregnancy Category:C
Breastfeeding: Safety unknown. As many drugs are excreted in human milk, manufacturer advises caution while administering to nursing mothers.