Adult Dosing

Allergic rhinitis

• 4 mg PO q4-6 hrs; Alt: 6-12 mg PO bid
• Max: 24 mg/day

Pediatric Dosing

Allergic rhinitis

• Children >12 yrs: 4 mg PO q4-6 hrs; Alt: 6-12 mg PO bid; Max: 24 mg/day
• Children 6-12 yrs: 2 mg PO q4-6 hrs; Alt: 6 mg PO bid; Max: 12 mg/day
• Children 2-5 yrs: 1 mg PO q4-6 hrs

• Temporary relief of symptoms associated with seasonal and perennial allergic rhinitis and vasomotor rhinitis

• Hypersensitivity to any of the ingredients of the products
• Concomitant use of monoamine oxidase inhibitor (MAOI) or within 14 days of MAOI use
• Narrow angle glaucoma
• Urinary retention
• Peptic ulcer
• Acute asthmatic attack
• Newborn or premature infants

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Liver cirrhosis: Dose adjustments not defined

See Supplemental Patient Information

• Brompheniramine can cause nervousness, dizziness, or sleeplessness, discontinue the drug if such symptoms occur
• Antihistamines produce paradoxical excitation in young children. Use of antihistamines is contraindicated in children <2 yrs
• Discontinue the drug if symptoms do not improve within 7 days or occur with a fever

Cautions: Use cautiously in

• Severe Hypertension
• Cardiovascular disease
• History of bronchial asthma
• Increased intraocular pressure
• Hyperthyroidism
• Prostatic hypertrophy
• Geriatric patients
• CNS depressant use

Supplemental Patient Information

• Advise patients to avoid driving a motor vehicle or operating machinery, as drowsiness can occur with this treatment
• Advise patients to avoid alcohol

Pregnancy Category:C

Breastfeeding: No adverse effects are seen in breastfed infants with small, occasional doses of brompheniramine. However larger doses or more prolonged use can cause effects in the infant or decrease the milk supply, particularly when used with a sympathomimetic such as pseudoephedrine or before lactation is well established. After the last feeding of the day single bed time dose may be adequate for many women and will minimize any effects of the drug. The preferred alternatives are nonsedating antihistamines. This information is based upon Lactmed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 17 May 2011).

• CNS: Drowsiness, sedation, dizziness, excitation (in children)
• EENT: Blurred vision
• CV: Hypertension, arrhythmias, hypotension, palpitations
• GI: Dry mouth, constipation, obstruction
• GU: Retention, urinary hesitancy
• DERM: Sweating

• Histamine H1 antagonist; acts as an antagonist of the H1 histamine receptors, also acts as anticholingeric agent
• Well absorbed from the GI tract after oral administration
• Metabolized by liver
• Renally excreted 40% (5-10% unchanged), feces 2%
• Half-life: 12-35 hrs

US Trade Name(s)

• Only generic available

US Availability

brompheniramine (generic)

• TABS: 4 mg

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

ENT

Antihistamines

Allergy & Immunology

Antihistamines