Adult Dosing
Pharyngitis and/or tonsillitis
Skin and soft tissue infections
- 1-2 g/day PO divided qd/bid
Urinary tract infections
- Uncomplicated UTI's: 1-2 g/day div qd/bid
- Complicated UTI's: 1 g PO bid
Note: The duration of treatment varies with the type and severity of infection
Pharyngitis (Acute) [Non-FDA Approved]
Pediatric Dosing
Pharyngitis and/or tonsillitis
- 30 mg/kg/day PO div qd/bid [Max: 1 g/day]
Skin and soft tissue infections
- 30 mg/kg/day PO divided bid [Max: 2 g/day]
Urinary tract infections
- 30 mg/kg PO div bid [Max: 2 g/day]
Note: The duration of treatment varies with the type and severity of infection
Pharyngitis (Acute) [Non-FDA Approved]
- 30 mg/kg/day PO qd [Max: 1 g/day]
[Outline]
Renal Dose Adjustment (Based on CrCl)
- 25-50 mL/min: 500 mg PO q12 hrs
- 10-25 mL/min: 500 mg PO q24 hrs
- 0-10 mL/min: 500 mg PO q36 hrs
Hepatic Dose Adjustment
- Hepatic impairment: Dose adjustments not defined
- Prior to initiating therapy determine whether the patient has had previous hypersensitivity reactions to cefadroxil, cephalosporins, penicillins, or other drugs
- Cautiously administer in penicillin sensitive patients as cross sensitivity may occur
- Suspend therapy on occurrence of an allergic reaction and treat accordingly if serious acute hypersensitivity takes place
- Clostridium difficile associated diarrhea which may vary in severity from mild to fatal colitis, has been reported with use of cefadroxil
- Careful clinical observation and appropriate laboratory studies should be made prior to and during therapy in patients with known or suspected renal impairment
- Use of therapy in strongly suspected bacterial infection or a prophylactic indication may increase the risk of the development of drug-resistant bacteria
- Careful observation is needed in prolonged use of therapy because prolonged use may result in the overgrowth of non-susceptible organism. Appropriate measures should be taken if superinfection occurs during therapy
- Administer cautiously in patients with hx of GI disease particularly colitis
Cautions: Use cautiously in
- Renal impairment
- Hypersensitivity to penicillin
- Hx of antibiotic associated colitis
- Hx of GI disease
Pregnancy Category:B
Breastfeeding: This drug is compatible and considered safe with breastfeeding based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776 ) and based upon LactMed database http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 30 December 2010). Manufacturer advises caution.
Pricing data from www.DrugStore.com in U.S.A.
- Cefadroxil 500 MG CAPS [Bottle] (LUPIN PHARMACEUTICALS)
30 mg = $35.99
60 mg = $71.97 - Cefadroxil 1 GM TABS [Bottle] (TEVA PHARMACEUTICALS USA)
30 gm = $139.99
60 gm = $279.98
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
