- Anaphylaxis, encephalitis including death, meningitis, neuroparalytic events such as encephalitis, transient paralysis, Guillain-Barre Syndrome, myelitis, retrobulbar neuritis and multiple sclerosis has occurred with use of this vaccine. Carefully consider a patient's risk of developing rabies before deciding to discontinue immunization
- Avoid using by subcutaneous or intradermal route
- Deltoid area is the preferred site of immunization for adults. Administration into the anterolateral zone of the thigh is preferred for small children and infants. Avoid using use of the gluteal region as administration in this area results in lower neutralizing antibody titers
- Avoid injecting intravascularly
- Systemic reactions, including shock have occurred on unintentional intravascular injection. Take immediate measures including catecholamines, volume replacement, high doses of corticosteroids, and oxygen
- Occurrence of active immunity after vaccination is impaired in immune-compromised individuals
- Take utmost care for the safe and effective use of the product. Ask patient's/caregivers about the current health status of the vaccine and reactions to a previous dose of this or a similar product
- Postpone preexposure vaccination in the case of sick and convalescent individuals, and those considered to be in the incubation stage of an infectious disease
- Use a separate, sterile syringe and needle or a sterile disposable unit for each patient to prevent transmission of hepatitis and other infectious agents from person to person
- Avoid recapping of needles and properly dispose them
- Consider possibility of hypersensitivity reactions in individuals hypersensitive to processed bovine gelatin and trace amounts of chicken protein, neomycin, chlortetracycline and amphotericin B
- Administer antihistamines in individuals having history of hypersensitivity is given rabies vaccine. Keep ready epinephrine (1:1000), volume replacement, corticosteroids and oxygen to counteract anaphylactic reactions
Cautions: Use cautiously in:
- Hypersensitivity to any of the ingredients of the product
- Hypersensitivity to albumin
- Hypersensitivity to bovine proteins
- Hypersensitivity to chicken proteins
- Hypersensitivity to neomycin
- Hypersensitivity to chlortetracycline
- Hypersensitivity to amphotericin B
- Concurrent immunosuppressants
- Immunosuppressed
Pregnancy Category:C
Breastfeeding: The centers for disease control and prevention and several health professional organizations informs that vaccines given to a nursing mother does not affect the safety of breastfeeding for mothers or infants and that breastfeeding is not a contraindication to rabies vaccine. Vaccinate breastfed infants according to the routine recommended schedules. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 14 February 2011). Unknown whether this vaccine is excreted in human milk. Although there are no literatures available, because of the potential consequences of inadequately treated rabies exposure, nursing is not considered a contraindication to postexposure prophylaxis. On substantial risk of exposure to rabies preexposure vaccination might be indicated during nursing.
Pricing data from www.DrugStore.com in U.S.A.
- RabAvert SUSR [Vial] (NOVARTIS VACCINES & DIAGNOSTIC)
1 = $275.98
2 = $529.94
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
2.5 International Units of rabies antigen (Human Diploid Cell)
