Adult Dosing
Inhalational anthrax due to bacillus anthracis
- 40 mg/kg IV as a single dose infused over 2 hours 15 minutes
- Premedicate with diphenhydramine 25-25 mg PO or IV within 1 hour prior to infusion
Pediatric Dosing
Inhalational anthrax due to bacillus anthracis
- <15 kg: 80 mg/kg IV
- 15 to 50 kg: 60 mg/kg IV
- >50 kg: 40 mg/kg IV
- Administer as a one-time single IV infusion over 2 hours 15 minutes
- Premedicate with diphenhydramine within 1 hour prior to infusion
Note:Safety and effectiveness in children <16 years of age not studied. There have been no studies of raxibacumab in the pediatric population. Dosing in pediatric patients was derived using a population PK approach.
[Outline]
Renal Dose Adjustment (Based on CrCl)
- Renal impairment: Dose adjustments not defined
Hepatic Dose Adjustment
- Hepatic impairment: Dose adjustments not defined
Pregnancy Category:B
Breastfeeding: Human immunoglobulins are excreted in human milk, published data suggest that neonatal consumption of human milk does not result in substantial absorption of these maternal immunoglobulins into circulation, however caution should be exercised when administered to a nursing woman
