Adult Dosing

Hypogonadotropic Hypogonadism In Males

• 500-1000 U IM 3 times weekly x 3 wks, followed by the same dose twice a week for three weeks
• Alt: 4,000 U IM 3 times weekly x 6-9 months, following which the dosage may be reduced to 2,000 USP U IM 3 times weekly for an additional three months

Induction of ovulation and pregnancy in the anovulatory, infertile woman

• 5000-10,000 U IM x1 one day following the last dose of menotropins

Pediatric Dosing

Prepubertal cryptorchidism not due to anatomical obstruction

• 4,000 U IM 3 times weekly x 3 wks
• 5,000 U IM qod x 4 doses
• 500-1000 U IM x 15 over 6 wks
• 500 U IM 3 times weekly x 4-6 wks
• If this course of treatment is not successful, another is begun one month later giving 1,000 USP Units per injection

[Outline]

• Adult Dosing
• Pediatric Dosing

• Prepubertal cryptorchidism not due to anatomical obstruction
• Induction of ovulation and pregnancy in the anovulatory, infertile woman
• Hypogonadotropic hypogonadism in males

• Hypersensitivity to any of the ingredients of the product
• Pregnancy
• Precocious puberty
• Prostate CA
• Androgen-dependent CA

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warnings, precautions and adverse reactions
• Therapy may cause ovarian hyperstimulation, rupture of ovarian cysts with resultant hemoperitoneum, multiple births and arterial thromboembolism
• Anaphylaxis and other hypersensitivity reactions have also been reported
• In patients treated for cryptorchidism, induction of androgen secretion by HCG may induce precocious puberty. Suspend therapy if signs of precocious puberty occur
• Use with caution in patients with cardiac or renal disease, epilepsy, migraine or asthma, as androgens may cause fluid retention

Cautions: Use cautiously in

• Renal impairment
• Cardiac disease
• Seizure disorder
• Migraine
• Asthma

Pregnancy Category:X

Breastfeeding: Safety unknown. Manufacturer advises caution.

• CNS: Headache, irritability, restlessness, depression, fatigue
• CV: Edema, thromboembolism
• REPRODUCTIVE: Ovarian cyst rupture, multiple pregnancy
• ENDO: Precocious puberty, gynecomastia, ovarian hyperstimulation syndrome
• LOCAL: Pain at the site of injection

• Polypeptide hormone; it stimulates ovarian progesterone production and testicular androgen production by stimulating the interstitial cells
• Metabolism: Unknown; CYP450: Unknown
• Excreted in the urine (10% unchanged)
• Half-life: 23-35 hrs

US Trade Name(s)

• Novarel
• Pregnyl

US Availability

chorionic gonadotropin (generic)

• PWDR for INJ: 10000 U/vial

Novarel

• PWDR for INJ: 10000 U/vial

Pregnyl

• PWDR for INJ: 10000 U/vial

Canadian Trade Name(s)

• Only generic available

Canadian Availability

chorionic gonadotropin (generic)

• PWDR for INJ: 10000 U/vial

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• Pregnyl

Australian Availability

Pregnyl

• PWDR for INJ: 500 U/amp
• PWDR for INJ: 1500 U/amp
• PWDR for INJ: 5000 U/amp

[Outline]

Endocrine/Metabolic

Sex Hormones

Gonadotropins

Obstetrics/Gynecology

Sex Hormones

Gonadotropins

Pricing data from www.DrugStore.com in U.S.A.

• Pregnyl 10000 UNIT SOLR [Vial] (ORGANON)
  1 unit = $69.22
  3 unit = $182.39
• Novarel 10000 UNIT SOLR [Vial] (FERRING)
  1 unit = $176
  3 unit = $499.97
• Chorionic Gonadotropin 10000 UNIT SOLR [Vial] (APP PHARMACEUTICAL)
  1 unit = $170
  3 unit = $479.99

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.